Liver Vessel Enhancement by Gd-BOPTA and Gd-EOB-DTPA: A Comparison in Healthy Volunteers
Liver Vessel Enhancement by Gd-BOPTA and Gd-EOB-DTPA: A Comparison in Healthy Volunteers
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DOI：
10.1080/02841850903055603
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发表时间：
2009-01-01
期刊：
影响因子：
1.3
通讯作者：
Albiin, N.
中科院分区：
文献类型：
--
作者：
Brismar, T. B.;Dahlstrom, N.;Albiin, N.
背景：对磁共振(MR)造影剂动力学的透彻了解使为每次检查选择最佳造影剂成为可能。目的：比较Gd-BOPTA(MultiHance)和Gd-EOB-DTPA(Primovist)对肝脏血管和肝实质的增强动力学。材料和方法：10名健康志愿者在注射造影剂前、动脉和门静脉期，以及注射造影剂后10、20、30、40和130分钟，测量肝实质、肝总动脉、肝中静脉和门静脉右段支的信号强度。由于扫描仪的限制，不是在肝静脉期。Gd-BOPTA和Gd-EOB-DTPA的对比剂剂量分别为0.1mmoL/kg和0.025 mmoL/kg。结果：Gd-BOPTA注射后130min和Gd-EOB-DTPA注射后10min~40min，肝实质强化最明显。两种造影剂对肝实质的最大强化程度无差异。Gd-BOPTA注射后40min血管增强仍明显，10min后血管增强消失。Gd-BOPTA组与Gd-EOB-DTPA组血管与肝实质信号最大差值明显大于Gd-EOB-DTPA组(P
Background: A thorough understanding of magnetic resonance (MR) contrast media dynamics makes it possible to choose the optimal contrast media for each investigation. Differences in visualizing hepatobiliary function between Gd-BOPTA and Gd-EOB-DTPA have previously been demonstrated, but less has been published regarding differences in liver vessel visualization.Purpose: To compare the liver vessel and liver parenchymal enhancement dynamics of Gd-BOPTA (MultiHance) and Gd-EOB-DTPA (Primovist).Material and Methods: The signal intensity of the liver parenchyma, the common hepatic artery, the middle hepatic vein, and a segmental branch of the right portal vein was obtained in 10 healthy volunteers before contrast media administration, during arterial and portal venous phases, and 10, 20, 30, 40, and 130 min after intravenous contrast medium injection, but, due to scanner limitations, not during the hepatic venous phase. The doses of contrast media were 0.1 mmol/kg for Gd-BOPTA and 0.025 mmol/kg for Gd-EOB-DTPA.Results: Maximum enhancement of liver parenchyma was observed from the portal venous phase until 130 min after Gd-BOPTA administration and from 10 min to 40 min after Gd-EOB-DTPA. There was no difference in maximum enhancement of liver parenchyma between the two contrast media. When using Gd-BOPTA, the vascular contrast enhancement was still apparent 40 min after injection, but had vanished 10 min after Gd-EOB-DTPA injection. The maximum difference in signal intensity between the vessels and the liver parenchyma was significantly greater with Gd-BOPTA than with Gd-EOB-DTPA (P