Acanthosis nigricans and diabetes risk factors: Prevalence in young persons seen in southwestern US primary care practices
Acanthosis nigricans and diabetes risk factors: Prevalence in young persons seen in southwestern US primary care practices
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DOI：
10.1370/afm.678
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发表时间：
2007-05-01
影响因子：
4.4
通讯作者：
Rhyne, Robert L.
中科院分区：
文献类型：
--
作者：
Kong, Alberta S.;Williams, Robert L.;Rhyne, Robert L.
研究目的：有证据表明黑棘皮病常与高胰岛素血症有关，并可能提示2型糖尿病风险增加。本研究的目的是确定黑棘皮病与2型糖尿病的危险因素和年轻人的疾病的关联。方法我们进行了一项横断面研究，在门诊设置网络的研究，在美国西南部社区的实践为基础的研究网络。参与的临床医生（N = 96）收集了在2周采样期内观察到的7至39岁儿童和年轻人的数据。主要结果是黑棘皮病的患病率、2型糖尿病的危险因素结果：在1,133例2型糖尿病患者中，69%的患者有2型糖尿病家族史，10%的患者有2型糖尿病家族史，10%的患者有2型糖尿病家族史，10%的患者有2型糖尿病家族史。3%的儿童（7至19岁）和12%的成年人患有高血压; 43%的儿童和73%的成年人超重或肥胖; 80%是少数民族成员。在17%的儿童和21%的成人中发现了黑色素沉着病。在儿童和成人中，2型糖尿病危险因素越多，黑棘皮病的患病率越高（P <0.001）。在控制了年龄、体重指数和2型糖尿病危险因素的数量后，黑棘皮病患者的2型糖尿病患病率为1.97（95%置信区间，1.18-3.27; P = 0.01）。临床医生报告说，黑棘皮病的鉴定经常导致讨论生活方式的改变，以降低2型diabetes.CONCLUSIONS的风险黑棘皮病患者可能有多种危险因素2型糖尿病。黑色素瘤可能是该病的独立危险因素。黑棘皮病的检测可能有助于临床医生更快地识别糖尿病咨询的高危人群。
PURPOSE Evidence shows acanthosis nigricans is often associated with hyperinsulinemia and may indicate increased risk of type 2 diabetes mellitus. The purpose of this study was to determine the association of acanthosis nigricans with type 2 diabetes risk factors and disease in young persons.METHODS We conducted a cross-sectional study in the Research in Outpatient Settings Network, a practice-based research network in southwestern US communities. Participating clinicians (N = 96) collected data on children and young adults aged 7 to 39 years seen during a 2-week sampling period. The main outcomes were the prevalence of acanthosis nigricans, type 2 diabetes risk factors (ethnicity, family history of type 2 diabetes, hypertension, overweight/obesity), type 2 diabetes, and the relationships among these.RESULTS Among 1,133 patients sampled, risk factors for type 2 diabetes were common: 69% had a family history of the disease; 3% of children (aged 7 to 19 years) and 12% of adults had hypertension; 43% of children and 73% of adults were overweight or obese; and 80% were members of ethnic minorities. Acanthosis nigricans was found in 17% of children and 21% of adults. Among children and adults alike, the more type 2 diabetes risk factors that were present, the higher the prevalence of acanthosis nigricans (P < .001). The prevalence ratio for type 2 diabetes in patients with acanthosis nigricans was 1.97 (95% confidence interval, 1.18-3.27; P = .01) after controlling for age, body mass index, and the number of type 2 diabetes risk factors. Clinicians reported that the identification of acanthosis nigricans frequently led to discussions about lifestyle modification for decreasing the risk of type 2 diabetes.CONCLUSIONS Patients with acanthosis nigricans are likely to have multiple risk factors for type 2 diabetes. Acanthosis nigricans may be an independent risk factor for this disease. Detection of acanthosis nigricans may help clinicians more rapidly identify high-risk individuals for diabetes counseling.