Emerging roles of GPER in diabetes and atherosclerosis.
Emerging roles of GPER in diabetes and atherosclerosis.
复制标题
DOI：
10.1016/j.tem.2015.02.003
复制
发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Prossnitz ER
中科院分区：
文献类型：
--
作者：
Barton M;Prossnitz ER
G蛋白偶联雌激素受体（GPER）是一种参与快速雌激素信号传导的7-跨膜受体。GPER最初是从血管内皮细胞中克隆出来的，在血管张力和细胞生长以及脂质和葡萄糖稳态的调节中起着核心作用。本文综述了GPER在胰腺、外周组织和免疫组织以及动脉血管中的生理和病理生理功能。最近的研究发现，它在肥胖、糖尿病和动脉粥样硬化中的作用，包括gper对脂质代谢和炎症的依赖调节。针对gper依赖通路在慢性疾病如冠状动脉疾病和糖尿病以及绝经背景下的治疗潜力也进行了讨论。
G protein-coupled estrogen receptor (GPER) is a 7-transmembrane receptor implicated in rapid estrogen signaling. Originally cloned from vascular endothelial cells, GPER plays a central role in the regulation of vascular tone and cell growth, as well as lipid and glucose homeostasis. This review highlights our knowledge of the physiological and pathophysiological functions of GPER in the pancreas, peripheral and immune tissues, and the arterial vasculature. Recent findings of its roles in obesity, diabetes, and atherosclerosis, including the GPER-dependent regulation of lipid metabolism and inflammation, are presented. The therapeutic potential of targeting GPER-dependent pathways in chronic diseases such as coronary artery disease and diabetes and in the context of menopause is also discussed.