The development of anticancer agent releasing microcapsule made of ferromagnetic amorphous flakes for intratissue hyperthermia
The development of anticancer agent releasing microcapsule made of ferromagnetic amorphous flakes for intratissue hyperthermia
复制标题
铁磁非晶薄片抗癌药物释放微胶囊的研制用于组织热疗
DOI：
10.1109/20.281165
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
S. Minakawa
中科院分区：
文献类型：
--
作者：
Tomoya Sato;A. Masai;Y. Ota;H. Sato;H. Matuski;T. Yanada;M. Sato;N. Kodama;S. Minakawa
对于组织内热疗，作者开发了一种使用由铁磁非晶金属薄片制成的微胶囊的加热方法，该微胶囊还能够释放抗癌剂。这些胶囊可以悬浮液的形式用于将它们注入肿瘤。胶囊在交变磁场（185 kHz）中产生热量，从而避免了体内产生热量。在一定的磁场强度下，胶囊的最高温度由非晶态金属的居里点决定。接近室温的居里点可以容易地以1摄氏度的增量设置。在达到最高温度后，胶囊本身将温度保持在+或-0.5摄氏度的精度内。在动物实验中，胶囊产生足够的热量用于组织内热疗，并增强抗癌剂的释放。>
For intratissue hyperthermia, the authors have developed a heating method using microcapsules made of ferromagnetic amorphous metal flakes that is additionally capable of releasing anticancer agents. The capsules can be used in a suspension to infuse them into a tumor. The capsules generate heat in an alternating magnetic field (185 kHz), which avoids heat generation in the body itself. At a certain intensity of the magnetic field, the maximum temperature of the capsule is determined by the Curie point of the amorphous metal. The Curie point near room temperature can be readily set in 1 degrees C increments. After reaching the maximum temperature, the capsule maintains temperature by itself within an accuracy of +or-0.5 degrees C. In animal experiments, the capsules generate sufficient heat for intratissue hyperthermia with enhanced releasing of the anticancer agent. >