Inside(sight) of tiny communicator: exosome biogenesis, secretion, and uptake
Inside(sight) of tiny communicator: exosome biogenesis, secretion, and uptake
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DOI：
10.1007/s11010-020-03703-z
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发表时间：
2020-02-22
影响因子：
4.3
通讯作者：
Patel, Vaibhav B.
中科院分区：
文献类型：
--
作者：
Jadli, Anshul S.;Ballasy, Noura;Patel, Vaibhav B.
在20世纪80年代后期发现的作为从网织红细胞分泌的内体起源的细胞外囊泡，外泌体由于其在细胞间通讯中的作用而最近获得了科学关注。现已鉴定外泌体携带核酸、蛋白质、脂质和其他生物活性分子的细胞特异性货物。外泌体可以被邻近或远处的细胞选择性地摄取，这已经显示在受体细胞中导致结构和功能反应。最近的进展表明外泌体在各个步骤中的调节，包括它们的生物发生、它们的货物的选择以及细胞特异性摄取。这篇综述将阐明细胞外囊泡类型之间的差异。在这篇综述中，我们讨论了我们的理解外泌体的生物发生，分泌和摄取的调节的最新进展。
Discovered in the late 1980s as an extracellular vesicle of endosomal origin secreted from reticulocytes, exosomes recently gained scientific attention due to its role in intercellular communication. Exosomes have now been identified to carry cell-specific cargo of nucleic acids, proteins, lipids, and other biologically active molecules. Exosomes can be selectively taken up by neighboring or distant cells, which has shown to result in structural and functional responses in the recipient cells. Recent advances indicate the regulation of exosomes at various steps, including their biogenesis, selection of their cargo, as well as cell-specific uptake. This review will shed light on the differences between the type of extracellular vesicles. In this review, we discuss the recent progress in our understanding of the regulation of exosome biogenesis, secretion, and uptake.