FGDF Motif Regulation of Stress Granule Formation
FGDF Motif Regulation of Stress Granule Formation
复制标题
DOI：
10.1089/dna.2015.2957
复制
发表时间：
2015-09-01
影响因子：
3.1
通讯作者：
McInerney, Gerald M.
中科院分区：
文献类型：
--
作者：
McInerney, Gerald M.
RNA 应激颗粒 (SG) 代表细胞固有的抗病毒防御机制。响应病毒感染的 SG 组装是由细胞蛋白 G3BP 协调的，许多病毒以 G3BP 为目标来阻止 SG 形成。我们最近表明，含有短线性基序 Phe-Gly-Asp-Phe (FGDF) 的蛋白质在核转运因子 2 样结构域表面的疏水沟中结合 G3BP。以这种方式结合会阻断 G3BP 形成 SG 的能力，并允许携带该基序的病毒有效复制。
RNA stress granules (SGs) represent a cell-intrinsic antiviral defense mechanism. The assembly of SGs in response to viral infection is coordinated by the cellular protein G3BP, which is targeted by many viruses to block SG formation. We recently showed that proteins containing the short linear motif Phe-Gly-Asp-Phe (FGDF), bind G3BP in a hydrophobic groove on the surface of the nuclear transport factor-2-like domain. Binding in this manner blocks the ability of G3BP to form SGs and allows efficient replication of viruses carrying this motif.