p53 codon 72 polymorphism and urothelial cancer risk
p53 codon 72 polymorphism and urothelial cancer risk
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DOI：
10.1016/s0304-3835(02)00518-9
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发表时间：
2003-01-10
期刊：
影响因子：
9.7
通讯作者：
Katoh, T
中科院分区：
文献类型：
--
作者：
Kuroda, Y;Tsukino, H;Katoh, T
p53肿瘤抑制基因在各种人类癌症中经常发生突变。最近，p53密码子72多态性已被广泛研究，以确定负责癌症形成的危险因素。我们调查了112例男性尿路上皮癌病例和175例男性无关非癌对照中p53密码子72多态性的基因型分布。日本非癌症对照的等位基因频率为0.58（Arg）和0.42（Pro）。p53基因第72密码子Arg/Arg、Arg/Pro、Pro/Pro三种基因型频率在尿路上皮癌组与对照组之间差异无统计学意义。然而，按吸烟状况分层，我们发现吸烟者的Pro/Pro基因型频率显著高于从不吸烟者（比值比（OR）= 2.28，95%可信区间（95%CI）= 1.12-4.66）。此外，我们将吸烟状况（包年数）分为四分位数（60）。01 - 02
The p53 tumor suppressor gene is often mutated in various human cancers. Recently, the p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for cancer formation. We investigated the genotype distribution of the p53 codon 72 polymorphism in 112 male urothelial cancer cases and 175 male unrelated non-cancer controls. The allelic frequencies in Japanese non-cancer controls were 0.58 (Arg) and 0.42 (Pro). There was no significant difference in the three genotype frequencies (Arg/Arg, Arg/Pro, Pro/Pro) of the p53 codon 72 between the urothelial cancer cases and the controls. However, stratifying by smoking status, we found that the frequency of the Pro/Pro genotype for smokers was significantly more than that for never-smokers (odds ratio (OR) = 2.28, 95% confidence interval (95%Cl) = 1.12-4.66). Furthermore, we divided smoking status (pack-years) into quartiles (60). OR (Pro/Pro vs. Arg/Arg) for the lighter smokers (