Risk of T-cell lymphomas in persons with AIDS
Risk of T-cell lymphomas in persons with AIDS
复制标题
DOI：
10.1097/00126334-200104010-00015
复制
发表时间：
2001-04-01
期刊：
影响因子：
--
通讯作者：
Goedert, JJ
中科院分区：
文献类型：
--
作者：
Biggar, RJ;Engels, EA;Goedert, JJ
艾滋病患者的淋巴瘤大多是B细胞型，但也有T细胞淋巴瘤的报道。我们通过将302，834名患有艾滋病的成年人与癌症登记数据联系起来，检查了艾滋病发病后2年内T细胞淋巴瘤的风险。在6，788例具有特定组织学类型的非霍奇金淋巴瘤（NHL）中，96例（1.4%）为T细胞淋巴瘤。评估基于临床诊断和组织学，因为T细胞标志物数据不足，但当存在时，标志物数据支持T细胞诊断。T细胞淋巴瘤的相对危险度，估计标准化发病率比，为15.0（95%置信区间：10.0-21.7）。所有亚型的风险都增加，包括蕈样肉芽肿、外周淋巴瘤、皮肤淋巴瘤和成人T细胞白血病/淋巴瘤（ATLL）。与艾滋病毒有关的免疫缺陷可能很重要，但发展艾滋病的人群与普通人群之间的差异（例如，例如，在一个实施例中，来自加勒比地区的ATLL移民）可能独立增加T细胞淋巴瘤的风险。
Lymphomas in persons with AIDS are mostly B-cell types, but T-cell lymphomas have also been reported. We examined T-cell lymphoma risk in the 2-year period after AIDS onset by linking 302,834 adults with AIDS to cancer registry data. Of 6,788 cases of non-Hodgkin's lymphoma (NHL) with specified histologies, 96 (1.4%) were T-cell lymphomas. Assessment was based on clinical diagnosis and histology because T-cell marker data were inadequate, but when present, marker data supported the T-cell diagnosis. The relative risk of T-cell lymphoma, estimated by standardized incidence ratio, was 15.0 (95% confidence interval: 10.0-21.7). Risks were increased for all subtypes, including mycosis fungoides, peripheral lymphomas, cutaneous lymphomas, and adult T-cell leukemia/lymphoma (ATLL). HIV-related immunodeficiency could be important, but differences between the population developing AIDS and the general population (e. g., immigration from the Caribbean region for ATLL) might independently increase T-cell lymphoma risk.