Neurogenic Hypertension and Elevated Vertebrobasilar Arterial Resistance: Is There a Causative Link?
Neurogenic Hypertension and Elevated Vertebrobasilar Arterial Resistance: Is There a Causative Link?
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DOI：
10.1007/s11906-012-0267-6
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发表时间：
2012-06-01
影响因子：
5.6
通讯作者：
Paton, Julian F. R.
中科院分区：
文献类型：
--
作者：
Cates, Matthew J.;Dickinson, C. John;Paton, Julian F. R.
有证据表明，交感神经麻痹在相当大比例的原发性高血压患者和动物模型的条件，自发性高血压大鼠（SHR）。其原因仍然难以捉摸。然而，也有证据表明，在SHR和高血压人群中，供应脑干的动脉变窄。在这篇综述中，我们讨论了脑干灌注不足在驱动交感神经活动增加和高血压中的可能作用。
There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and hypertensive humans. In this review, we discuss the possible role of brainstem hypoperfusion in driving increased sympathetic activity and hypertension.