Concurrent Infection with Hepatitis C Virus and Streptococcus pneumoniae
Concurrent Infection with Hepatitis C Virus and Streptococcus pneumoniae
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DOI：
10.3201/eid2307.161858
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发表时间：
2017-07-01
影响因子：
11.8
通讯作者：
Eurich, Dean T.
中科院分区：
文献类型：
--
作者：
Marrie, Thomas J.;Tyrrell, Gregory J.;Eurich, Dean T.
丙型肝炎病毒（HCV）和肺炎链球菌（Streptococcus pneumoniae）的并发感染引起侵袭性肺炎球菌病（IPD）的情况知之甚少。我们假设HCV和S.肺炎会增加死亡和并发症的风险。我们在2000-2014年期间在加拿大北方阿尔伯塔进行的一项基于人群的队列研究中采集了成人IPD患者的社会人口统计学和血清学数据。采用多因素logistic回归分析比较感染HCV的IPD患者与未感染HCV的IPD患者的院内死亡和并发症风险。在3,251例IPD患者中，共有355例合并感染HCV。感染HCV的IPD患者的住院死亡率较高。大多数IPD相关并发症的患病率（例如，蜂窝织炎、急性肾损伤、机械通气）在HCV感染患者中也较高。HCV感染在IPD患者中很常见，并且HCV与严重疾病和死亡的风险增加独立相关。
Little is known about concurrent infection with hepatitis C virus (HCV) and Streptococcus pneumoniae, which causes invasive pneumococcal disease (IPD). We hypothesized that co-infection with HCV and S. pneumoniae would increase risk for death and complications. We captured sociodemographic and serologic data for adults with IPD in a population-based cohort study in northern Alberta, Canada, during 2000-2014. IPD patients infected with HCV were compared with IPD patients not infected with HCV for risk of in-hospital deaths and complications by using multivariable logistic regression. A total of 355 of 3,251 patients with IPD were co-infected with HCV. The in-hospital mortality rate was higher for IPD patients infected with HCV. Prevalence of most IPD-related complications (e.g., cellulitis, acute kidney injury, mechanical ventilation) was also higher in HCV-infected patients. Infection with HCV is common in patients with IPD, and HCV is independently associated with an increased risk for serious illness and death.