Sequence Polymorphism and Evolution of Three Cetacean MHC Genes
Sequence Polymorphism and Evolution of Three Cetacean MHC Genes
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三种鲸类MHC基因的序列多态性和进化
DOI：
10.1007/s00239-009-9272-z
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发表时间：
2009-08
影响因子：
3.9
通讯作者：
Xu, Shi Xia
中科院分区：
文献类型：
--
作者：
Zhou, Kai Ya;Wei, Fu Wen;Ren, Wen Hua;Li, Shu Zhen;Yang, Guang;Xu, Shi Xia
为了全面了解鲸目动物组织相容性复合体(MHC)的进化，对鲸目动物3个主要组织相容性复合体(MHC)基因(DQB、DRA和MHC-I)的序列变异进行了研究。在DRA基因座上检测到的序列变异很小，而在MHC-I和DQB基因座上发现了广泛而可观的变异。系统发育重建和序列比较表明，在所研究的三个MHC基因座上，不同物种之间存在着广泛的相同的MHC等位基因。将这些MHC基因座的系统发育树与仅基于非PBR位点构建的树进行比较，发现等位基因的相似性/同一性可能反映了共同的祖先，而不是由于适应性收敛。同时，根据松弛的分子时钟，三个MHC基因座的等位基因多样性明显提前了物种分化事件，同时也证明了跨物种进化。可能是平衡选择的力量在MHC-I和DQB基因座以反式特异的方式维持了高度的序列变异性和相同的等位基因。
Sequence variability at three major histocompatibility complex (MHC) genes (DQB,DRA, and MHC-I) of cetaceans was investigated in order to get an overall understanding of cetacean MHC evolution. Little sequence variation was detected at theDRAlocus, while extensive and considerable variability were found at the MHC-I andDQBloci. Phylogenetic reconstruction and sequence comparison revealed extensive sharing of identical MHC alleles among different species at the three MHC loci examined. Comparisons of phylogenetic trees for these MHC loci with the trees reconstructed only based on non-PBR sites revealed that allelic similarity/identity possibly reflected common ancestry and were not due to adaptive convergence. At the same time, trans-species evolution was also evidenced that the allelic diversity of the three MHC loci clearly pre-dated species divergence events according to the relaxed molecular clock. It may be the forces of balancing selection acting to maintain the high sequence variability and identical alleles in trans-specific manner at the MHC-I andDQBloci.
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影响因子：
5.8
作者：
Posada, D;Crandall, KA
通讯作者：
Crandall, KA
影响因子：
4.9
作者：
Munguia-Vega, Adrian;Esquer-Garrigos, Yareli;Flores-Ramirez, Sergio
通讯作者：
Flores-Ramirez, Sergio
影响因子：
4.1
作者：
Shixia Xu;Bingyao Chen;K. Zhou;Guang Yang
通讯作者：
Shixia Xu;Bingyao Chen;K. Zhou;Guang Yang
影响因子：
--
作者：
Guang Yang;Sha Liu;Wenhua Ren;K. Zhou;F. Wei
通讯作者：
Guang Yang;Sha Liu;Wenhua Ren;K. Zhou;F. Wei
影响因子：
3.2
作者：
Bowen, L;Aldridge, BM;Johnson, ML
通讯作者：
Johnson, ML