Effects of auditory hallucinations on the mismatch negativity (MMN) in schizophrenia as measured by a modified 'optimal' multi-feature paradigm
Effects of auditory hallucinations on the mismatch negativity (MMN) in schizophrenia as measured by a modified 'optimal' multi-feature paradigm
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DOI：
10.1016/j.ijpsycho.2011.06.018
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发表时间：
2011-09-01
影响因子：
3
通讯作者：
Knott, Verner J.
中科院分区：
文献类型：
--
作者：
Fisher, Derek J.;Grant, Bryan;Knott, Verner J.
最近开发的OPTIME-3多特征MMN范例是“最佳”多特征MMN范例的简化版本，允许在有效且节省时间的范例内集中记录最广泛报道的MMN偏差(频率、持续时间、强度)。本研究的目的是检测精神分裂症(SZ)患者MMN的声学变化，并探讨其与幻听(AH)的关系。方法：记录12例SZ门诊持续性AHS患者(SZ)和12例健康对照(HC)的MMN对时程、频率和强度的影响。记录32个头皮电极的电活动；比较各组间MMN波幅和潜伏期，并与SZ的AH严重程度的特质(PSYRATS)和状态测量以及阳性和阴性症状量表(PANSS)评分相关。结果：SZS的MMN持续时间明显短于HCS。此外，在SZ中，持续时间的MMN波幅与PSYRATS评分的增加以及PANSS阳性症状、幻觉项目和一般精神质评分的增加相关，而强度MMN的波幅衰减与PSYRATS评分的增加相关。结论：这是首次在改良的(最佳-3)多特征MMN范式下研究SZ的MMN。这项研究证实了之前报道的深圳地区持续时间较长的MMN缺乏症，并支持了先前的研究结果，即AHS可能导致SZ的MMN缺乏症。(C)2011爱思唯尔B.V.保留所有权利。
The recently developed Optimal-3 multi-feature MMN paradigm, a shortened version of the 'optimal' multi-feature MMN paradigm, allows for the focused recording of the most widely reported MMN deviants (frequency, duration, intensity) within an efficient and time-saving paradigm. The objective of this study was to examine MMN acoustic change detection in schizophrenia (SZ), and elucidate its association with auditory verbal hallucinations (AH), using the Optimal-3.Methods: MMN to duration, frequency and intensity deviants were recorded in 12 SZ outpatients (SZs) with persistent AHs and 12 matched healthy controls (HC). Electrical activity was recorded from 32 scalp electrodes; MMN amplitudes and latencies for each deviant were compared between groups and were correlated with trait (PSYRATS) and state measures of AH severity and Positive and Negative Syndrome Scale (PANSS) ratings in SZs.Results: SZs showed a significantly smaller duration MMN compared to HCs. Furthermore, in SZs attenuated duration MMN amplitudes were correlated with increased PSYRATS scores, as well as increased PANSS positive symptom, hallucination item and general psychoticism ratings, while attenuated intensity MMN amplitudes were correlated with increased PSYRATS scores.Conclusions: This is the first study to examine MMN in SZ within the modified (Optimal-3) multi-feature MMN paradigm. This study corroborates previous research reporting a robust duration MMN deficit in SZ and supports previous findings suggesting that AHs may contribute to MMN deficits in SZ. (C) 2011 Elsevier B.V. All rights reserved.