dUev1a modulates TNF-JNK mediated tumor progression and cell death in Drosophila
dUev1a modulates TNF-JNK mediated tumor progression and cell death in Drosophila
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dUev1a 调节 TNF-JNK 介导的果蝇肿瘤进展和细胞死亡
DOI：
10.1016/j.ydbio.2013.05.013
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发表时间：
2013-08-15
影响因子：
2.7
通讯作者：
Xue, Lei
中科院分区：
文献类型：
--
作者：
Ma, Xianjue;Yang, Lixia;Xue, Lei
细胞极性的丧失与致癌RAS协同诱导JNK依赖的肿瘤生长和侵袭。为了确定更多调控肿瘤进展的基因，我们在果蝇中进行了基因筛查，发现哺乳动物Uev1的同源基因dUev1a的缺失抑制了LGL(-/-)/RAS(V12)诱导的JNK介导的肿瘤生长和侵袭。此外，缺失dUev1a可抑制肿瘤坏死因子原Eiger诱导的JNK介导的细胞侵袭和细胞死亡。最后，dUev1a通过dTRAF2与Bless协同激活JNK信号。综上所述，我们的数据表明，dUev1a编码进化保守的肿瘤坏死因子-JNK信号通路的重要组成部分，该信号通路调节后生动物的肿瘤进展和细胞死亡。(C)2013 Elsevier Inc.保留所有权利。
Loss of cell polarity cooperates with oncogenic Ras to induce JNK-dependent tumor growth and invasion. To identify additional genes that modulate tumor progression, we have performed a genetic screen in Drosophila and found that loss of dUev1a, the ortholog of mammalian Uev1, suppressed lgl(-/-)/Ras(V12) induced JNK-mediated tumor growth and invasion. Furthermore, loss of dUev1a suppressed TNF ortholog Eiger-induced JNK-mediated cell invasion and cell death. Finally, dUev1a cooperated with Bendless to activate JNK signaling through dTRAF2. Together, our data indicate that dUev1a encodes an essential component of the evolutionary conserved TNF-JNK signaling pathway that modulates tumor progression and cell death in metazoan. (c) 2013 Elsevier Inc. All rights reserved.