INITIAL HERPES-SIMPLEX VIRUS TYPE-1 INFECTION PREVENTS GANGLIONIC SUPER-INFECTION BY OTHER STRAINS
INITIAL HERPES-SIMPLEX VIRUS TYPE-1 INFECTION PREVENTS GANGLIONIC SUPER-INFECTION BY OTHER STRAINS
复制标题
DOI：
10.1128/iai.35.3.1125-1132.1982
复制
发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
KAUFMAN, HE
中科院分区：
文献类型：
--
作者：
CENTIFANTOFITZGERALD, YM;VARNELL, ED;KAUFMAN, HE
用相对良性的疱疹病毒株（E-43）感染兔神经节，用两种神经营养性强毒株（MP或McKrae）攻击兔神经节，发现只有最初的良性感染株在兔神经节定殖。当动物感染MP或McKrae菌株时，E-43菌株的原发感染导致较轻的疾病，并且还防止了这些菌株在神经节中的定殖。抗糖蛋白C中和、空斑形态、细胞病变、重组实验和限制性内切酶分析表明，从神经节中回收的病毒是最初感染的E-43株;没有发现攻击MP和McKrae菌株的痕迹。攻击McKrae菌株在少数动物中脱落数周，但从这些动物的三叉神经节分离的病毒是主要感染的E-43株。因此，初始感染相对良性的疱疹病毒株可能会防止神经节（但不一定是终末器官）的高度毒力单纯疱疹病毒株的重复感染，并可能在考虑对这种疾病的免疫在人类有显着的影响。
The ganglia of rabbits infected with a relatively benign strain of herpesvirus (E-43) and challenged with either of 2 virulent neurotrophic strains (MP or McKrae) were found to be colonized only by the initial benign infecting strain. Primary infection with the E-43 strain resulted in milder disease when the animals were infected with MP or McKrae strains and also prevented colonization of the ganglion by these strains. Neutralization with anti-glycoprotein C, plaque morphology, cytopathic effects, reconstruction experiments and restriction endonuclease analysis indicated that the virus recovered from the ganglion was the initial infecting E-43 strain; no traces of the challenging MP and McKrae strains were found. The challenging McKrae strain was shed for several wk in a few animals, but the virus isolated from the trigeminal ganglia of these animals was the primary infecting E-43 strain. Thus, initial infection with a relatively benign strain of herpes virus may prevent superinfection of the ganglion (but not necessarily the end organ) by highly virulent herpes simplex virus strains and could have significant implications in the consideration of immunization against this disease in humans.