Colonization with cagA-positive Helicobacter pylori strains inversely associated with reflux esophagitis and Barrett's esophagus
Colonization with cagA-positive Helicobacter pylori strains inversely associated with reflux esophagitis and Barrett's esophagus
复制标题
DOI：
10.1159/000007801
复制
发表时间：
2000-01-01
期刊：
影响因子：
3.2
通讯作者：
Kuipers, EJ
中科院分区：
文献类型：
--
作者：
Loffeld, RJLF;Werdmuller, BFM;Kuipers, EJ
目的：验证cagA（+）幽门螺杆菌定殖可预防胃食管反流病（GERD）及其并发症的假设。方法：对反流性食管炎和Barrett食管患者进行研究。取胃窦活检标本检测H、幽门螺杆菌，取血清标本检测H、幽门螺杆菌和CagA蛋白IgG抗体。结果：共纳入736例患者。反流性食管炎118例，Barrett食管36例，无炎症征象的裂孔疝108例（反流组），食管癌或胃癌20例。262例反流性疾病患者幽门螺杆菌患病率（34.9%）明显低于对照组(54.6%；在310例可获得血清的幽门螺杆菌阳性患者中，对照组中检测到cagA（+）菌株的定殖率为59%，而反流组为35% （p < 0.001）。结论：反流性食管炎和Barrett食管患者的H，幽门螺杆菌定殖率显著低于对照组，特别是cagA（+）型。这些数据表明，cagA(+) H，幽门螺杆菌菌株的定植可能对GERD的发展有保护作用。巴塞尔协议。
Aim: The hypothesis that colonization with cagA(+) Helicobacter pylori strains protects against the development of gastroesophageal reflux disease (GERD) and its complications is tested. Methods: Patients with reflux esophagitis and Barrett's esophagus were studied. Antral biopsy specimens were obtained for detection of H, pylori, A serum sample was obtained for determination of IgG antibodies to H, pylori and to the CagA protein. Results: 736 patients were studied. 118 patients had reflux esophagitis, 36 had Barrett's esophagus, 108 had hiatal hernia without signs of inflammation (the reflux group), and 20 patients had esophageal or stomach cancer. The remaining 454 patients had no signs of GERD, The 262 patients with reflux disease had a significantly lower prevalence of H, pylori (34.9%) than the 454 controls (54.6%; p < 0.001), Among 310 H, pylori-positive patients from whom serum was available, colonization with cagA(+) strains was detected in 59% in the control group versus 35% in the reflux group (p < 0.001), Conclusion: Patients with reflux esophagitis and Barrett's esophagus have a significantly lower prevalence of H, pylori colonization than controls, in particular of the cagA(+) type. These data suggest that colonization with cagA(+) H, pylori strains may be protective against the development of GERD Copyright (C) 2000 S. Karger AG. Basel.