Morphology and therapeutic chances of interstitial lung disease.
Morphology and therapeutic chances of interstitial lung disease.
复制标题
间质性肺疾病的形态学和治疗机会。
DOI：
10.1159/000194076
复制
发表时间：
1979
期刊：
影响因子：
--
通讯作者：
I. Mieth
中科院分区：
文献类型：
--
作者：
H. Otto;I. Mieth
本文对101例经肺活检确诊的特发性间质性肺病的临床和X线表现进行了回顾性分析，特别是对激素治疗的反应。可区分出四种形态学炎症反应：（1）肺泡炎;（2）洋葱样间充质增生;（3）结节样病变和（4）淋巴滤泡反应。特别是1型和/或2型显示对类固醇治疗的立即反应。只有少数病例显示自发改善。一旦纤维化存在，就不能指望任何地方的“恢复原状”。从这组特发性间质性肺疾病中得出的结论似乎是合理的，即其他类型的间质性肺反应也应使用类固醇治疗，以避免其转化为肺纤维化。
101 cases of idiopathic interstitial lung disease diagnosed by lung biopsy, were reviewed according to clinical and X-ray appearance and especially to their response to steroid therapy. Four morphological inflammatory reactions are distinguished: (1) alveolitis; (2) onion-like mesenchymal proliferation; (3) sarcoid-like lesions, and (4) lymphofollicular reactions. Especially type 1 and/or type 2 show immediate response to steroid therapy. Only a few cases showed spontaneous improvement. Once a fibrosis exists, a 'restitutio ad integrum' cannot be expected any where. From this group of idiopathic interstitial lung diseases the conclusion seems to be justified that also other types of interstitial lung reactions should be treated with steroids to avoid it turning into lung fibrosis.