Parity and the risk of pancreatic cancer: A nested case‐control study
Parity and the risk of pancreatic cancer: A nested case‐control study
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产次与胰腺癌风险：一项巢式病例对照研究
DOI：
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发表时间：
1998
影响因子：
6.4
通讯作者：
A. Ekbom
中科院分区：
文献类型：
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作者：
B. Karlson;J. Wuu;C. Hsieh;M. Lambe;A. Ekbom
吸烟是唯一被普遍接受的胰腺癌风险因素。在最近的研究中，生殖史与胰腺癌有关，但结果却相互矛盾。为了评估初产年龄和出生数量与胰腺癌之间的可能联系，我们通过连接两个瑞典全国性登记处：癌症登记处和生育登记处进行了一项嵌套病例对照研究。在1925年至1970年出生的女性中，1015名胰腺癌患者与5073名年龄匹配的对照组进行了比较。没有发现胰腺癌和出生人数之间的联系。头胎年龄与胰腺癌风险呈负相关（OR / 5年= 0.90;95% CI 0.83<0R> - <0B>0.97; p<0B> = 0.01），这种关联主要局限于50岁前诊断为胰腺癌的女性（OR / 5年= 0.85;95% CI 0.73<0R> - <0B>1.00; p<0B> = 0.04）。这一趋势在调整为平价后仍然存在，但不那么突出了。然而，在瑞典，年轻的第一胎和高胎次与吸烟的频率增加有关，因此，至少在某些情况下，年轻的第一胎妇女患胰腺癌的风险增加可能是由吸烟作为混杂因素来解释的。Int。[j]中华医学杂志，1998。©1998 Wiley‐Liss, Inc。
Smoking is the only generally accepted risk factor for pancreatic cancer. Reproductive history has in recent studies been associated with pancreatic cancer, but with contradictory results. In order to evaluate a possible association between age at first birth and the number of births and pancreatic cancer, we conducted a nested case‐control study by linking 2 Swedish nationwide registries: the Cancer Registry and The Fertility Registry. Among women born between 1925 and 1970, 1,015 patients with pancreatic cancer were compared with 5,073 age‐matched controls. No association between pancreatic cancer and number of births was found. Age at first birth was inversely related with the risk of pancreatic cancer (OR per 5 years = 0.90; 95% CI 0.83<0R>–<0B>0.97; p<0B> = 0.01), an association mainly confined to women with a diagnosis of pancreatic cancer before 50 years of age (OR per 5 years = 0.85; 95% CI 0.73<0R>–<0B>1.00; p<0B> = 0.04). This trend remained after adjustment for parity, but was less prominent. Young age at first birth and high parity in Sweden are, however, associated with an increased frequency of smoking, thus at least some of the increased risk for pancreatic cancer in women with young age at first birth is likely to be explained by smoking acting as a confounder. Int. J. Cancer 77:224–227, 1998. © 1998 Wiley‐Liss, Inc.
人类生育能力与寿命之间的关系。
影响因子：
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作者：
Kuningas, Maris;Altmae, Signe;Uitterlinden, Andre G.;Hofman, Albert;van Duijn, Cornelia M.;Tiemeier, Henning
通讯作者：
Tiemeier, Henning