Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary veno-occlusive disease
Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary veno-occlusive disease
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DOI：
10.1378/chest.113.1.237
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发表时间：
1998-01-01
期刊：
影响因子：
9.6
通讯作者：
Tapson, SF
中科院分区：
文献类型：
--
作者：
Palmer, SM;Robinson, LJ;Tapson, SF
肺静脉闭塞症(PVOD)是一种罕见的与肺小静脉纤维性闭塞相关的肺高压。尽管血管扩张剂治疗在许多原发性肺动脉高压患者中是有效的，但由于担心引起肺水肿，血管扩张剂在PVOD中的作用尚不清楚。然而，最近有报道称，口服血管扩张剂或静脉注射前列环素对PVOD患者治疗成功。相比之下，描述了一名PVOD患者，他在小剂量前列环素输注过程中出现急性肺水肿和呼吸衰竭，导致死亡。这份报告建议血管扩张剂，特别是前列环素，在已知的PVOD患者中必须极其谨慎地使用。
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension associated with fibrotic occlusion of the smaller pulmonary veins. Although vasodilator therapy is effective in many patients with primary pulmonary hypertension, the role of vasodilators in PVOD is unclear because of concerns about precipitating pulmonary edema. Recently, however, there have been reports of successful therapy with oral vasodilators or intravenous administration of prostacyclin in patients with PVOD. In contrast, a patient with PVOD is described who developed acute pulmonary edema and respiratory failure during low-dose prostacyclin infusion, leading to death. This report suggests that vasodilators, especially prostacyclin, must be used with extreme caution in patients with known PVOD.