Theranostics in nuclear medicine practice.
Theranostics in nuclear medicine practice.
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DOI：
10.2147/ott.s140671
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发表时间：
2017
影响因子：
4
通讯作者：
Essler M
中科院分区：
文献类型：
--
作者：
Yordanova A;Eppard E;Kürpig S;Bundschuh RA;Schönberger S;Gonzalez-Carmona M;Feldmann G;Ahmadzadehfar H;Essler M
个性化医疗的重要性一直在增长，主要是因为更迫切需要避免不必要和昂贵的治疗。在核医学中，治疗诊断方法是用于诊断和治疗的特定分子靶向的既定工具。潜在目标的可视化可以帮助预测患者是否会从特定治疗中受益。由于放射性药物和诊断技术的快速发展，治疗诊断剂的使用不断增加。在本文中，重点介绍了治疗诊断学背景下核治疗和诊断的重要里程碑。它从对甲状腺癌患者进行众所周知的放射性碘治疗开始，然后通过各种方法通过靶向治疗治疗晚期癌症。本综述的目的是提供背景知识和当前应用的总结，并确定靶向治疗和成像在核医学实践中的优势。
The importance of personalized medicine has been growing, mainly due to a more urgent need to avoid unnecessary and expensive treatments. In nuclear medicine, the theranostic approach is an established tool for specific molecular targeting, both for diagnostics and therapy. The visualization of potential targets can help predict if a patient will benefit from a particular treatment. Thanks to the quick development of radiopharmaceuticals and diagnostic techniques, the use of theranostic agents has been continually increasing. In this article, important milestones of nuclear therapies and diagnostics in the context of theranostics are highlighted. It begins with a well-known radioiodine therapy in patients with thyroid cancer and then progresses through various approaches for the treatment of advanced cancer with targeted therapies. The aim of this review was to provide a summary of background knowledge and current applications, and to identify the advantages of targeted therapies and imaging in nuclear medicine practices.