Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system
Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor system
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DOI：
10.1016/j.biopsych.2006.07.003
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发表时间：
2007-04-15
影响因子：
10.6
通讯作者：
Fredrikson, Mats
中科院分区：
文献类型：
--
作者：
Michelgard, Asa;Appel, Lieuwe;Fredrikson, Mats
背景：动物研究表明，压力和负面情绪会增强神经肽物质 P (SP) 的释放，该物质与神经激肽 I (NK1) 受体结合。这项正电子发射断层扫描 (PET) 研究评估了患有特定恐惧症的受试者杏仁核 SP-NK1 受体系统的活动如何受到恐惧挑衅的影响。方法：16 名患有 DSM-IV 定义的对蛇或蜘蛛的特定恐惧症的成年女性，但不是同时观看令人恐惧和不恐惧的动物的图片，同时使用高度特异性的 NK1 受体拮抗剂进行 PET 扫描 60 分钟[C-11]GR205171 作为标记的 PET 示踪剂。结果：在恐惧刺激期间，右侧杏仁核对标记的 NK1 受体拮抗剂的摄取显着减少。在左侧杏仁核中，恐惧和非恐惧条件之间没有发现显着差异。在右侧杏仁核中，主观焦虑评分与 NK1 示踪剂结合之间不存在负相关，但在左侧杏仁核中则不然。结论：恐惧刺激会影响右侧杏仁核中的 SP-NK1 受体系统。这反映出恐惧期间 NK1 受体的可用性降低，并可能反映出内源性物质 P 释放的增加。
Background: Animal studies demonstrate that stress and negative affect enhance the release of the neuropeptide substance P (SP), which binds to the neurokinin I (NK1) receptor. This positron emission tomography (PET) study evaluated how the activity in the SP-NK1 receptor system in the amygdala was affected by fear provocation in subjects with specific phobia.Methods: Sixteen adult women with DSM-IV-defined specific phobia for either snakes or spiders but not both viewed pictures of feared and non-feared animals while being PET-scanned for 60 min with the highly specific NK1 receptor antagonist [C-11]GR205171 as the labeled PET tracer.Results: The uptake of the labeled NK1 receptor antagonist was significantly reduced in the right amygdala during phobic stimulation. In the left amygdala no significant differences were found between phobic and non-phobic conditions. There was a negative correlation in the right, but not left, amygdala between subjective anxiety ratings and NK1 tracer binding.Conclusions: Fear provocation affects the SP-NK1 receptor system in the right amygdala. This reflects reduced NK1 receptor availability during fear and could mirror an increased release of endogenous substance P.