A common hub for sleep and motor control in the substantia nigra
A common hub for sleep and motor control in the substantia nigra
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DOI：
10.1126/science.aaz0956
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发表时间：
2020-01-24
期刊：
影响因子：
56.9
通讯作者：
Dan, Yang
中科院分区：
文献类型：
--
作者：
Liu, Danqian;Li, Weifu;Dan, Yang
大脑的觉醒状态随动物的运动状态而变化。这些州的变化是如何协调的尚不清楚。我们发现睡眠-觉醒状态和运动行为是由黑质网状部（SNr）的共享神经元共同调控的。对小鼠家笼行为的分析确定了四种不同程度的大脑觉醒和运动活动状态：运动、非运动、安静清醒和睡眠；过渡不是随机发生的，而是主要发生在相邻的州之间。在低运动和觉醒状态下，γ -氨基丁酸（GABA）释放（GABA能）神经元的谷氨酸脱羧酶2 （glutamic acid decaraxylase 2）而不是小蛋白亚群（parvalbumin）优先活跃。它们的激活或失活分别偏向于自然行为转变的方向，促进或抑制睡眠。这些gaba能神经元整合广泛的输入，并通过广泛的侧支投射支配多个唤醒促进和运动控制回路。
The arousal state of the brain covaries with the motor state of the animal. How these state changes are coordinated remains unclear. We discovered that sleep-wake brain states and motor behaviors are coregulated by shared neurons in the substantia nigra pars reticulata (SNr). Analysis of mouse home-cage behavior identified four states with different levels of brain arousal and motor activity: locomotion, nonlocomotor movement, quiet wakefulness, and sleep; transitions occurred not randomly but primarily between neighboring states. The glutamic acid decarboxylase 2 but not the parvalbumin subset of SNr gamma-aminobutyric acid (GABA)-releasing (GABAergic) neurons was preferentially active in states of low motor activity and arousal. Their activation or inactivation biased the direction of natural behavioral transitions and promoted or suppressed sleep, respectively. These GABAergic neurons integrate wide-ranging inputs and innervate multiple arousal-promoting and motor-control circuits through extensive collateral projections.