Mast cell and basophil development.
Mast cell and basophil development.
复制标题
肥大细胞和嗜碱性粒细胞发育。
DOI：
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发表时间：
1994
影响因子：
3.2
通讯作者：
I. Hammel
中科院分区：
文献类型：
--
作者：
S. Galli;I. Hammel
肥大细胞和嗜碱性粒细胞在介质含量、组织化学特征和功能方面表现出某些显著的相似性。然而现在大量证据表明肥大细胞和嗜碱性细胞谱系是不同的。干细胞因子是c-kit受体的配体，是啮齿类和灵长类动物肥大细胞的主要生长因子，可调节肥大细胞的分泌功能。此外，影响干细胞因子受体或干细胞因子的异常可能导致某些肥大细胞增多症或肥大细胞肿瘤。相比之下，嗜碱性粒细胞可以独立于干细胞因子发育，并且对干细胞因子对介质分泌的影响不像肥大细胞那样敏感。此外，细胞因子白细胞介素-3极大地增加人嗜碱性粒细胞的产生，但对人肥大细胞几乎没有或没有生长促进活性。
Mast cells and basophils express certain remarkable similarities in mediator content, histochemical characteristics, and function. Yet a large body of evidence now indicates that the mast cell and basophil lineages are distinct. Stem cell factor, the ligand for the receptor encoded by c-kit, is a major growth factor for mast cells in both rodent and primate species, and can modulate mast cell secretory function. Moreover, abnormalities affecting the stem cell factor receptor or stem cell factor might contribute to some cases of mastocytosis or mast cell neoplasms. By contrast, basophils can develop independently of stem cell factor, and are not as sensitive as mast cells to the effects of stem cell factor on mediator secretion. In addition, the cytokine interleukin-3 greatly augments the production of human basophils, but has little or no growth promoting activity for human mast cells.