Cooperation and heterogeneity of the autistic mind.
Cooperation and heterogeneity of the autistic mind.
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DOI：
10.1523/jneurosci.0400-10.2010
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发表时间：
2010-06-30
期刊：
影响因子：
--
通讯作者：
Dolan RJ
中科院分区：
文献类型：
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作者：
Yoshida W;Dziobek I;Kliemann D;Heekeren HR;Friston KJ;Dolan RJ
自闭症谱系障碍（ASC）患者在递归推断他人意图方面存在核心困难。然而，决定这一谱系核心异质性的确切认知功能障碍仍不清楚。此外，社会互动障碍仍有可能不是一种基本缺陷，而是不同认知过程缺陷的反映。为了更好地理解ASC内部的异质性，我们采用了博弈论的方法来描述社会互动中隐含的不可观察的计算过程。通过对自闭症成年人进行社交狩猎游戏，我们发现，代表他人策略复杂程度的选择性难度，即推断他人的读心术策略，可以特别预测症状的严重程度。相比之下，迭代计划能力的降低是由整体智力水平预测的。我们的发现提供了第一个定量方法，可以揭示产生自闭症“谱系”的潜在计算功能障碍。
Individuals with autism spectrum conditions (ASC) have a core difficulty in recursively inferring the intentions of others. The precise cognitive dysfunctions that determine the heterogeneity at the heart of this spectrum, however, remains unclear. Furthermore, it remains possible that impairment in social interaction is not a fundamental deficit but a reflection of deficits in distinct cognitive processes. To better understand heterogeneity within ASC, we employed a game-theoretic approach to characterise unobservable computational processes implicit in social interactions. Using a social hunting game with autistic adults, we found that a selective difficulty representing the level of strategic sophistication of others, namely inferring others’ mindreading strategy, specifically predicts symptom severity. In contrast, a reduced ability in iterative planning was predicted by overall intellectual level. Our findings provide the first quantitative approach that can reveal the underlying computational dysfunctions that generate the autistic ‘spectrum’.