Novel treatment strategies for brain tumors and metastases.
Novel treatment strategies for brain tumors and metastases.
复制标题
DOI：
10.4155/ppa.14.19
复制
发表时间：
2014-05
影响因子：
1.3
通讯作者：
Nounou MI
中科院分区：
文献类型：
--
作者：
El-Habashy SE;Nazief AM;Adkins CE;Wen MM;El-Kamel AH;Hamdan AM;Hanafy AS;Terrell TO;Mohammad AS;Lockman PR;Nounou MI
本文综述了近5年来治疗脑肿瘤和脑转移的专利申请。大多数最近的专利讨论了以下策略之一：开发针对脑细胞、血脑屏障和肿瘤细胞的新药物实体，量身定制一种能够执行多任务和多功能的新型载体系统，作为药物载体、靶向载体甚至作为诊断工具，将美国FDA批准的药物与靶向部分、诊断部分或PK修饰部分直接结合，或使用创新的非传统方法，如基因工程、干细胞和疫苗接种。到目前为止，还没有一种最佳的策略将治疗剂输送到中枢神经系统来治疗脑肿瘤和转移瘤。目前正在积极开展深入的研究工作，将脑肿瘤靶向以及新型和靶向的中枢神经系统输送系统应用于潜在的临床应用。
This review summarizes patent applications in the past 5 years for the management of brain tumors and metastases. Most of the recent patents discuss one of the following strategies: the development of new drug entities that specifically target the brain cells, the blood–brain barrier and the tumor cells, tailor-designing a novel carrier system that is able to perform multitasks and multifunction as a drug carrier, targeting vehicle and even as a diagnostic tool, direct conjugation of a US FDA approved drug with a targeting moiety, diagnostic moiety or PK modifying moiety, or the use of innovative nontraditional approaches such as genetic engineering, stem cells and vaccinations. Until now, there has been no optimal strategy to deliver therapeutic agents to the CNS for the treatment of brain tumors and metastases. Intensive research efforts are actively ongoing to take brain tumor targeting, and novel and targeted CNS delivery systems to potential clinical application.