Homing in: Mechanisms of Substrate Targeting by Protein Kinases.
Homing in: Mechanisms of Substrate Targeting by Protein Kinases.
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DOI：
10.1016/j.tibs.2018.02.009
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发表时间：
2018-05
影响因子：
13.8
通讯作者：
Turk BE
中科院分区：
文献类型：
--
作者：
Miller CJ;Turk BE
蛋白磷酸化是真核生物中最常见的可逆翻译后修饰。人类有超过500种蛋白激酶，其中超过12种是抗癌药物的既定目标。所有的激酶都有一个结构相似的催化结构域，但每个激酶在控制细胞行为的所有方面的信号网络中都有独特的位置。激酶是根据它们的调节模式和底物谱来区分的。将特定的输入耦合到适当的信号输出需要激酶磷酸化有限数量的位点，从而排除数十万个脱靶磷酸化位点。在这里，我们回顾了最近在理解激酶底物特异性机制以及它们如何作用于形成细胞信号网络方面的进展。
Protein phosphorylation is the most common reversible posttranslational modification in eukaryotes. Humans have over 500 protein kinases, of which more than a dozen are established targets for anti-cancer drugs. All kinases share a structurally similar catalytic domain, yet each one is uniquely positioned within signaling networks controlling essentially all aspects of cell behavior. Kinases are distinguished from one another based on their modes of regulation and their substrate repertoires. Coupling specific inputs to the proper signaling outputs requires that kinases phosphorylate a limited number of sites to the exclusion of hundreds of thousands of off-target phosphorylation sites. Here, we review recent progress in understanding mechanisms of kinase substrate specificity and how they function to shape cellular signaling networks.
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影响因子：
4
作者：
Chen C;Nimlamool W;Miller CJ;Lou HJ;Turk BE
通讯作者：
Turk BE
影响因子：
16
作者：
Chen, Catherine;Ha, Byung Hak;Thevenin, Anastasia F.;Lou, Hua Jane;Zhang, Rong;Yip, Kevin Y.;Peterson, Jeffrey R.;Gerstein, Mark;Kim, Philip M.;Filippakopoulos, Panagis;Knapp, Stefan;Boggon, Titus J.;Turk, Benjamin E.
通讯作者：
Turk, Benjamin E.
影响因子：
64.5
作者：
Creixell P;Schoof EM;Simpson CD;Longden J;Miller CJ;Lou HJ;Perryman L;Cox TR;Zivanovic N;Palmeri A;Wesolowska-Andersen A;Helmer-Citterich M;Ferkinghoff-Borg J;Itamochi H;Bodenmiller B;Erler JT;Turk BE;Linding R
通讯作者：
Linding R
影响因子：
7.3
作者：
Alexander J;Lim D;Joughin BA;Hegemann B;Hutchins JR;Ehrenberger T;Ivins F;Sessa F;Hudecz O;Nigg EA;Fry AM;Musacchio A;Stukenberg PT;Mechtler K;Peters JM;Smerdon SJ;Yaffe MB
通讯作者：
Yaffe MB
影响因子：
16
作者：
Furdui, CM;Lew, ED;Anderson, KS
通讯作者：
Anderson, KS