Effects of extracerebral dopamine (DA) on salsolinol (SAL)- or thyrotropin-releasing hormone (TRH)- induced prolactin (PRL) secretion in goats
Effects of extracerebral dopamine (DA) on salsolinol (SAL)- or thyrotropin-releasing hormone (TRH)- induced prolactin (PRL) secretion in goats
复制标题
脑外多巴胺 (DA) 对山羊草酚 (SAL) 或促甲状腺素释放激素 (TRH) 诱导的催乳素 (PRL) 分泌的影响
DOI：
10.1111/asj.12586
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发表时间：
2016
影响因子：
2
通讯作者：
Hashizume T.
中科院分区：
文献类型：
--
作者：
Inaba Y.;Kato Y.;Itou A.;Chiba A.;Sawai K.;Fulop F.;Nagy G.;Hashizume T.
本研究的目的是阐明脑外多巴胺（DA）对山羊salsolinol （SAL）诱导的催乳素（PRL）分泌的影响。在脑外DA受体拮抗剂多潘立酮（DOM）治疗前后，雌性山羊静脉注射SAL或促甲状腺激素释放激素（TRH），比较SAL和TRH对PRL释放的反应。DOM单独增加血浆PRL浓度，并且DOM单独释放PRL的反应大于SAL单独或TRH单独释放PRL的反应。DOM + SAL对PRL的释放反应与单独使用DOM相似，DOM和SAL对PRL的分泌没有加性作用。相比之下，DOM + TRH的PRL释放反应大于TRH单独或DOM单独，DOM协同增加TRH诱导的PRL分泌。目前的研究结果表明，SAL与TRH分泌PRL的机制不同，并提示脑外DA可能部分与SAL诱导山羊PRL分泌的调节有关。
The aim of the present study was to clarify the effect of extracerebral dopamine (DA) on salsolinol (SAL)‐induced prolactin (PRL) secretion in goats. An intravenous injection of SAL or thyrotropin‐releasing hormone (TRH) was given to female goats before and after treatment with an extracerebral DA receptor antagonist, domperidone (DOM), and the PRL‐releasing response to SAL was compared with that to TRH. DOM alone increased plasma PRL concentrations and the PRL‐releasing response to DOM alone was greater than that to either SAL alone or TRH alone. The PRL‐releasing response to DOM plus SAL was similar to that to DOM alone, and no additive effect of DOM and SAL on the secretion of PRL was observed. In contrast, the PRL‐releasing response to DOM plus TRH was greater than that to either TRH alone or DOM alone and DOM synergistically increased TRH‐induced PRL secretion. The present results demonstrate that the mechanism involved in PRL secretion by SAL differs from that by TRH, and suggest that the extracerebral DA might be associated in part with the modulation of SAL‐induced PRL secretion in goats.