Krause corpuscles of the genitalia are vibrotactile sensors required for normal sexual behavior.
Krause corpuscles of the genitalia are vibrotactile sensors required for normal sexual behavior.
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生殖器的克劳斯小体是正常性行为所需的振动触觉传感器。
DOI：
10.1101/2023.06.14.545006
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Ginty,DavidD
中科院分区：
文献类型：
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作者：
Qi,Lijun;Iskols,Michael;Handler,Annie;Ginty,DavidD
克劳斯小体于 1850 年代首次发现，是在生殖器和其他皮肤粘膜组织中发现的神秘感觉结构，具有未知的生理特性和功能。在这里，我们确定了两种不同的体感神经元亚型，它们支配小鼠阴茎和阴蒂的克劳斯小体，并投射到脊髓的独特感觉末端区域。利用体内电生理学和钙成像，我们发现两种克劳斯小体传入类型都是 A 纤维快速适应低阈值机械感受器，最适合应用于阴蒂或阴茎的动态、轻触和机械振动 (40-80 Hz)。男性克劳斯小体传入末梢的光遗传学激活引起阴茎勃起，而克劳斯小体的基因消融会损害男性的插入和射精，并降低女性的性接受能力。因此，阴蒂中特别密集的克劳斯小体是对正常性行为至关重要的振动触觉传感器。
Krause corpuscles, first discovered in the 1850s, are enigmatic sensory structures with unknown physiological properties and functions found within the genitalia and other mucocutaneous tissues. Here, we identified two distinct somatosensory neuron subtypes that innervate Krause corpuscles of the mouse penis and clitoris and project to a unique sensory terminal region of the spinal cord. Using in vivo electrophysiology and calcium imaging, we found that both Krause corpuscle afferent types are A-fiber rapid-adapting low-threshold mechanoreceptors, optimally tuned to dynamic, light touch and mechanical vibrations (40-80 Hz) applied to the clitoris or penis. Optogenetic activation of male Krause corpuscle afferent terminals evoked penile erection, while genetic ablation of Krause corpuscles impaired intromission and ejaculation of males as well as reduced sexual receptivity of females. Thus, Krause corpuscles, which are particularly dense in the clitoris, are vibrotactile sensors crucial for normal sexual behavior.