Losing the rose tinted glasses: neural substrates of unbiased belief updating in depression
Losing the rose tinted glasses: neural substrates of unbiased belief updating in depression
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DOI：
10.3389/fnhum.2014.00639
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发表时间：
2014-08-28
影响因子：
2.9
通讯作者：
Dolan, Raymond J.
中科院分区：
文献类型：
--
作者：
Garrett, Neil;Sharot, Tali;Dolan, Raymond J.
近期的证据表明，良好的心理健康状态与对支持对未来持积极偏向观点的信息的偏向性处理有关。另一方面，抑郁症则与对这类信息的无偏向性处理有关。在此，我们将脑成像与对临床抑郁症患者和健康对照者实施的信念更新任务相结合，以描述支持临床抑郁症患者无偏向性信念更新的大脑活动特征。我们的研究结果显示，抑郁症患者的无偏向性信念更新是由对有关未来的好消息（在左侧额下回和双侧额上回）和坏消息（在右侧顶下小叶和右侧额下回）的估计误差的强烈神经编码所介导的。相比之下，心理健康则与对有关未来的坏消息的相对较弱的神经编码有关。这些发现确定了一种介导重性抑郁症中偏向性更新的破坏的神经基础，这可能对心理健康至关重要。
Recent evidence suggests that a state of good mental health is associated with biased processing of information that supports a positively skewed view of the future. Depression, on the other hand, is associated with unbiased processing of such information. Here, we use brain imaging in conjunction with a belief update task administered to clinically depressed patients and healthy controls to characterize brain activity that supports unbiased belief updating in clinically depressed individuals. Our results reveal that unbiased belief updating in depression is mediated by strong neural coding of estimation errors in response to both good news On left inferior frontal gyrus and bilateral superior frontal gyrus) and bad news On right inferior parietal lobule and right inferior frontal gyrus) regarding the future. In contrast, intact mental health was linked to a relatively attenuated neural coding of bad news about the future. These findings identify a neural substrate mediating the breakdown of biased updating in major depression disorder, which may be essential for mental health.