Micro-cloud point extraction for preconcentration of Aspirin in commercial tablets prior to spectrophotometric determination
Micro-cloud point extraction for preconcentration of Aspirin in commercial tablets prior to spectrophotometric determination
复制标题
DOI：
10.1134/s1061934816080074
复制
发表时间：
2016-07
影响因子：
1.1
通讯作者：
M. Kaykhaii;E. Ghasemi
中科院分区：
文献类型：
--
作者：
M. Kaykhaii;E. Ghasemi
建立了一种快速、简便、经济、有效的微浊点萃取分光光度法测定市售片剂中阿司匹林的方法。提出的MCPE基本上是一个小型化的形式，传统的浊点萃取（CPE），其中只有几微升的胶束萃取相是足够的分光光度测定。为了与MCPE进行比较，检查了用于阿司匹林提取的浊点提取。Triton X-114作为非离子表面活性剂用于萃取/预浓缩阿司匹林。考察了Triton浓度、pH值、稀释剂种类等因素对萃取效率的影响。在优化条件下，MCPE的线性范围为0.05 ~ 2 mg/L，检出限为0.05mg/L; CPE的线性范围为0.9 ~ 11 mg/L，检出限为0.5mg/L。
A fast, simple, inexpensive and effective method is developed for spectrophotometric determination of Aspirin in commercial tablets based on micro-cloud point extraction (MCPE). The proposed MCPE is essentially a miniaturized form of traditional cloud point extraction (CPE) in which only a few microliters of micellar extracting phase is sufficient for spectrophotometric determination. For comparison with MCPE, cloud point extraction was examined for Aspirin extraction. Triton X-114 was employed as a non-ionic surfactant for extraction/preconcentration of aspirin. Factors influencing the extraction efficiency, such as concentration of Triton, effect of pH, type of dilution solvent, etc. were investigated and optimized. Under the optimized condition, linear calibration curve for MCPE was in the range of 0.05–2 mg/L and limit of detection of 0.05 mg/L was obtained, whereas linear part for CPE calibration curve was 0.9 to 11 mg/L with a limit of detection of 0.5 mg/L.