Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota
Myricetin supplementation decreases hepatic lipid synthesis and inflammation by modulating gut microbiota
复制标题
补充杨梅素可通过调节肠道微生物群来减少肝脏脂质合成和炎症
DOI：
10.1016/j.celrep.2021.109641
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发表时间：
2021-08-31
期刊：
影响因子：
8.8
通讯作者：
Ji, Hong-Fang
中科院分区：
文献类型：
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作者：
Sun, Wen-Long;Li, Xin-Yu;Ji, Hong-Fang
对于许多黄酮类化合物，体内生物利用度差与有效药理活性之间的关系尚未完全阐明。分析类黄酮诱导的肠道微生物群的变化代表了一种有前途的方法，为阐明作用机制提供了有用的线索。在这里，我们研究了补充杨梅素对高脂饮食（HFD）诱导的大鼠非酒精性脂肪性肝病（NAFLD）的影响，并通过高通量分析探索与肠道微生物群的相关性。12周的杨梅素补充和粪便微生物群移植结果表明，杨梅素显著减缓了NAFLD的发展。同时，杨梅素的抗NAFLD作用与肠道微生物群组成的调节有关。杨梅素通过调节粪便丁酸相关肠道菌群和保护肠道屏障功能来减少肝脏脂质合成和炎症。本研究有助于阐明生物利用度低的黄酮类化合物的作用机制。
The relationship between poor in vivo bioavailability and effective pharmacological activity are not yet fully clarified for many flavonoids. The analysis of flavonoids-induced alterations in the gut microbiota represents a promising approach to provide useful clues to elucidate the mechanism of action. Here, we investigate the effect of myricetin supplementation on high-fat-diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) in rats and explore the associations with the gut microbiota through high-throughput analyses. The 12-week myricetin supplementation and fecal microbiota transplantation outcomes suggest that myricetin significantly slows the development of NAFLD. Meanwhile, the anti-NAFLD effects of myricetin are associated with the modulation of the gut microbiota composition. Myricetin reduces hepatic lipid synthesis and inflammation through modulations in fecal butyric-acid-related gut microbiota and protection of the gut barrier function. This study may facilitate the elucidation of the action mechanism of flavonoids with low bioavailability.