A MODIFIED HOT-PLATE TEST SENSITIVE TO MILD ANALGESICS
A MODIFIED HOT-PLATE TEST SENSITIVE TO MILD ANALGESICS
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DOI：
10.1016/0166-4328(86)90088-4
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发表时间：
1986-08-01
影响因子：
2.7
通讯作者：
HOLE, K
中科院分区：
文献类型：
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作者：
HUNSKAAR, S;BERGE, OG;HOLE, K
本研究比较了一种改进的热板试验，其中温度从无毒水平缓慢增加，与标准恒温热板试验。在这两个测试中，后爪舔被认为是一个更可靠的标准反应比前爪舔，并在整个实验中采用。在恒温热板试验中，在试验前一天暴露于试验装置1分钟显著降低了大鼠和小鼠的反应延迟。在升温试验中未发现预暴露的影响。在两个试验和两个物种中，进行了重复试验，试验之间的反应性仅发生了不显著的变化。在大鼠和小鼠中，在给药吗啡、对乙酰氨基酚和乙酰水杨酸后，在升温热板试验中获得了反应温度的剂量相关性增加，而在恒温试验中只有吗啡具有一致的作用。因此，在大鼠和小鼠中，升温热板是一种有用的比色试验，在结果的一致性和对非麻醉性镇痛药的敏感性方面优于常规热板试验上级。
The present study compared a modified hot-plate test in which the temperature is slowly increased from non-noxious levels with a standard constant temperature hot-plate test. In both tests, hindpaw lick was found to be a more reliable criterion response than forepaw lick, and was employed throughout the experiments. In the constant temperature hot-plate test, 1-min exposure to the test apparatus the day before testing significantly reduced the response latencies of both rats and mice. No effect of pre-exposure was found in the increasing temperature test. In both tests and in both species, sessions of repeated testing were conducted with only insignificant alterations in responsiveness between trials. In both rats and mice, dose-related increases in response temperature were obtained in the increasing temperature hot-plate test after administration of morphine, paracetamol and acetylsalicylic acid, whereas only morphine had consistent effects in the constant temperature test. Thus, the increasing temperature hot-plate is a useful analgesimetric test in both rats and mice, superior to the conventional hot-plate test with regard to consistency of results and sensitivity to non-narcotic analgesics.