Hormonal control of regional fat distribution.
Hormonal control of regional fat distribution.
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DOI：
10.1093/humrep/12.suppl_1.21
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发表时间：
1997-10
影响因子：
6.1
通讯作者：
P. Björntorp
中科院分区：
文献类型：
--
作者：
P. Björntorp
激素对人体脂肪分布有很大的影响。在完全受控条件下的体外研究表明，皮质醇和胰岛素通过表达脂蛋白脂肪酶（LPL）促进脂质蓄积。生长激素（GH）消除了这一点，并将代谢转向脂质动员。睾酮和GH能显著抑制LPL，促进脂解。皮质醇效应通过糖皮质激素受体介导，睾酮效应通过雄激素受体介导，其密度在内脏脂肪组织中似乎高于皮下脂肪组织。受体介导的效应可能通过适当基因的转录来表达。女性性类固醇也调节脂肪组织代谢，但显然不是直接在缺乏特定的细胞受体。雌激素似乎发挥类似于睾酮的净效应。细胞研究的这些结果与不同脂肪组织区域中甘油三酯摄取和周转的体内研究一致。此外，具有激素水平特征性紊乱的临床实体显示出预期的再分布模式。
Hormones exert powerful influences on body fat distribution in humans. Studies under fully controlled conditions in vitro have indicated that cortisol and insulin facilitate lipid accumulation by expressing lipoprotein lipase (LPL). Growth hormone (GH) abolishes this and turns metabolism towards lipid mobilization. Testosterone and GH inhibit LPL and stimulate lipolysis markedly. Cortisol effects are mediated via a glucocorticoid receptor, and testosterone effects via an androgen receptor, the density of which appears to be higher in visceral than subcutaneous adipose tissue. The receptor-mediated effects are probably expressed via transcription of appropriate genes. The female sex steroids also regulate adipose tissue metabolism, but apparently not directly in the absence of specific cellular receptors. Oestrogens seem to exert net effects similar to those of testosterone. These results of cellular studies agree well with in-vivo studies of triglyceride uptake and turnover in different adipose tissue regions. Furthermore, clinical entities with characteristic disturbances in hormone levels show the expected redistribution patterns.