Association between adult height, genetic susceptibility and risk of glioma
Association between adult height, genetic susceptibility and risk of glioma
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DOI：
10.1093/ije/dys114
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发表时间：
2012-08-01
影响因子：
7.7
通讯作者：
Rajaraman, Preetha
中科院分区：
文献类型：
--
作者：
Kitahara, Cari M.;Wang, Sophia S.;Rajaraman, Preetha
一些但不是全部的观察性研究表明，较高的身高与胶质瘤风险显著增加相关。在一个汇总分析的观察性研究，我们调查了这种关联的强度和一致性，整体和主要的亚型，并调查了遗传易感性对疾病的影响修改。方法我们标准化和合并个人水平的数据1354例和4734对照组13个前瞻性和2个病例对照研究。使用按性别分层的逻辑回归模型估计神经胶质瘤和神经胶质瘤亚型的合并优势比（OR）和95%置信区间（CI），并根据出生队列和研究进行调整。根据最近发现的七种胶质瘤相关的遗传变异对模型进行分层后，进一步估计了合并OR。（170 -174 cm，合并OR = 1.70，95% CI：1.11-2.61; P趋势= 0.01），在限制为胶质母细胞瘤病例后略强（合并OR = 1.99，95% CI：1.17-3.38; P趋势= 0.02）。在女性中，这些相关性不太清楚（175 cm vs 160-164 cm，胶质瘤的合并OR = 1.06，95% CI：0.70-1.62; P趋势= 0.22;胶质母细胞瘤的合并OR = 1.36，95% CI：0.77-2.39; P趋势= 0.04）。在一般情况下，我们没有观察到证据的影响修改胶质瘤相关基因型之间的关联高度和胶质瘤risk.Conclusion高的成人身高与胶质瘤，特别是男性和胶质母细胞瘤更强的关联，应进一步研究，以澄清这种疾病的病因高度的环境和遗传因素的作用。
Background Some, but not all, observational studies have suggested that taller stature is associated with a significant increased risk of glioma. In a pooled analysis of observational studies, we investigated the strength and consistency of this association, overall and for major sub- types, and investigated effect modification by genetic susceptibility to the disease.Methods We standardized and combined individual-level data on 1354 cases and 4734 control subjects from 13 prospective and 2 case-control studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) for glioma and glioma sub-types were estimated using logistic regression models stratified by sex and adjusted for birth cohort and study. Pooled ORs were additionally estimated after stratifying the models according to seven recently identified glioma-related genetic variants.Results Among men, we found a positive association between height and glioma risk (epsilon 190 vs 170-174 cm, pooled OR = 1.70, 95% CI: 1.11-2.61; P-trend = 0.01), which was slightly stronger after restricting to cases with glioblastoma (pooled OR = 1.99, 95% CI: 1.17-3.38; P-trend = 0.02). Among women, these associations were less clear (epsilon 175 vs 160-164 cm, pooled OR for glioma = 1.06, 95% CI: 0.70-1.62; P-trend = 0.22; pooled OR for glioblastoma = 1.36, 95% CI: 0.77-2.39; P-trend = 0.04). In general, we did not observe evidence of effect modification by glioma-related genotypes on the association between height and glioma risk.Conclusion An association of taller adult stature with glioma, particularly for men and stronger for glioblastoma, should be investigated further to clarify the role of environmental and genetic determinants of height in the etiology of this disease.