Brain regions underlying response inhibition and interference monitoring and suppression
Brain regions underlying response inhibition and interference monitoring and suppression
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DOI：
10.1111/j.1460-9568.2006.04680.x
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发表时间：
2006-03-01
影响因子：
3.4
通讯作者：
Mattay, VS
中科院分区：
文献类型：
--
作者：
Blasi, G;Goldberg, TE;Mattay, VS
反应抑制和干扰监测与抑制是认知控制的两个重要方面。以前的功能成像研究表明，这些认知过程背后的大脑区域有一个共同的网络：背外侧前额叶皮质(DLPFC)、腹外侧前额叶皮质(VLPFC)、背扣带回(DACC)和顶叶皮质(PC)。然而，这些区域对这些认知子过程的相对贡献还没有确定。基于先前支持dACC在监测刺激内相互冲突的信息中的作用的发现，我们假设在干扰监测和抑制期间，相对于反应抑制，大脑皮层区域有更大的活动。另一方面，由于反应抑制的特点是不同的认知过程，如控制实施、反应的自上而下调制、预期和行为反应的抑制，我们假设认知控制网络中其他皮质节点的活动增加与干扰监测和抑制有关。为此，我们在57名健康志愿者中进行了一项事件相关功能磁共振成像(FMRI)研究，使用了一项优先涉及干扰监测和抑制或反应抑制的任务。反应抑制的准确性低于干扰监测和抑制。影像数据显示DLPFC、DACC、VLPFC、PC在两种情况下均有激活。两种状态之间的比较表明，在反应抑制期间，DLPFC、VLPFC和PC的双侧激活程度更高，而在干扰监测和抑制期间，dACC的激活程度更大。这些结果扩展了先前的发现，提出了支持认知控制的皮质网络中的区域功能专门化。
Response inhibition and interference monitoring and suppression are two important aspects of cognitive control. Previous functional imaging studies have suggested a common network of brain regions underlying these cognitive processes; the dorsolateral prefrontal cortex (DLPFC), the ventrolateral prefrontal cortex (VLPFC), the dorsal cingulate (dACC), and the parietal cortex (PC). The relative contribution of these regions to these cognitive subprocesses, however, has not been determined. Based on previous findings supporting a role for dACC in the monitoring of conflicting information within a stimulus, we hypothesized greater activity in this cortical region during interference monitoring and suppression relative to response inhibition. On the other hand, as response inhibition is characterized by differential cognitive processes such as control implementation, top down modulation of the response, expectancy, and inhibition of behavioural response, we hypothesized increased activity in the other cortical nodes of the cognitive control network relative to interference monitoring and suppression. To this end, we conducted an event-related functional magnetic resonance imaging (fMRI) study in 57 healthy volunteers using a task preferentially involving either interference monitoring and suppression or response inhibition. Accuracy for response inhibition was lower than for interference monitoring and suppression. Imaging data showed activation in DLPFC, dACC, VLPFC, PC for both conditions. Comparisons between the two conditions indicated greater activation bilaterally in DLPFC, VLPFC and PC during response inhibition, and greater activation in the dACC during interference monitoring and suppression. These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control.