Randomised controlled trial of video clips and interactive games to improve vision in children with amblyopia using the I-BiT system
Randomised controlled trial of video clips and interactive games to improve vision in children with amblyopia using the I-BiT system
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DOI：
10.1136/bjophthalmol-2015-307798
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发表时间：
2016-11-01
影响因子：
4.1
通讯作者：
Foss, Alexander J. E.
中科院分区：
文献类型：
--
作者：
Herbison, Nicola;MacKeith, Daisy;Foss, Alexander J. E.
传统的弱视治疗包括配戴眼罩或阿托品惩罚较好的眼睛。在虚拟现实技术的基础上，一种新的治疗方法正在开发中，它允许DVD片段或电脑游戏向双眼和前景呈现共同的背景，其中包含感兴趣的图像，仅对弱视的眼睛。方法对4 ~ 8岁三臂弱视患者进行随机对照试验。所有的三个手臂都使用百叶窗玻璃技术进行双眼刺激。一只手臂向弱视的眼睛播放DVD片段和共同的背景，另一只手臂使用改进的射击游戏《Nux》，将精灵和目标呈现给弱视的眼睛（以及两者的背景），而第三只手臂的背景和前景同时呈现给两只眼睛（非交互式双目治疗（非i - bit）游戏）。结果随机分组75例患者；残残性弱视67例，伴斜视70例。在6周时，所有三只手臂的弱视眼的视力都提高了约0.07 logMAR。在视觉增益方面，I-BiT DVD和非I-BiT游戏与I-BiT游戏（陈述的主要结果）没有区别。结论：三组患者的视力均有适度改善。治疗耐受性好且安全。三种治疗方法在主要预后方面没有差异，但治疗时间较短，并且先前治疗过的弱视和斜视弱视的高比例不利复视刺激治疗。试验注册号NCT01702727，结果。
Background Traditional treatment of amblyopia involves either wearing a patch or atropine penalisation of the better eye. A new treatment is being developed on the basis of virtual reality technology allowing either DVD footage or computer games which present a common background to both eyes and the foreground, containing the imagery of interest, only to the amblyopic eye.Methods A randomised control trial was performed on patients with amblyopia aged 4-8years with three arms. All three arms had dichoptic stimulation using shutter glass technology. One arm had DVD footage shown to the amblyopic eye and common background to both, the second used a modified shooter game, Nux, with sprite and targets presented to the amblyopic eye (and background to both) while the third arm had both background and foreground presented to both eyes (non-interactive binocular treatment (non-I-BiT) games).Results Seventy-five patients were randomised; 67 were residual amblyopes and 70 had an associated strabismus. The visual acuity improved in all three arms by approximately 0.07 logMAR in the amblyopic eye at 6weeks. There was no difference between I-BiT DVD and non-I-BiT games compared with I-BiT games (stated primary outcome) in terms of gain in vision.Conclusions There was a modest vision improvement in all three arms. Treatment was well tolerated and safe. There was no difference between the three treatments in terms of primary stated outcomes but treatment duration was short and the high proportion of previously treated amblyopia and strabismic amblyopia disadvantaged dichoptic stimulation treatment.Trial registration number NCT01702727, results.