Serum adiponectin and resistin levels in major depressive disorder
Serum adiponectin and resistin levels in major depressive disorder
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DOI：
10.1111/j.1600-0447.2009.01463.x
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发表时间：
2010-03-01
影响因子：
6.7
通讯作者：
Hintikka, J.
中科院分区：
文献类型：
--
作者：
Lehto, S. M.;Huotari, A.;Hintikka, J.
目的：探讨脂肪组织来源的低度炎症标志物脂联素和抵抗素在重度抑郁障碍(MDD)发病中的作用。方法：检测70例DSM-IV MDD患者和70例健康对照的血清脂联素和抵抗素水平。用29项汉密尔顿抑郁量表评定抑郁严重程度。结果：MDD组血清脂联素水平降低。调整了年龄、性别、超重、多种社会经济和生活方式因素、冠心病和代谢综合征的回归模型显示，血清脂联素每降低5.0mU/ml，患MDD的可能性增加约20%(P=0.01)。抵抗素水平与非典型抑郁症状相关(P=0.02)，与典型抑郁症状无关(P=0.12)。结论：MDD患者脂联素水平降低是抑郁症特有的，不能用冠心病、代谢紊乱等传统的低脂联素相关因素来解释。
Objective:To examine the role of the adipose-tissue-derived low-grade inflammation markers adiponectin and resistin in major depressive disorder (MDD) in a population-based sample.Method:Serum levels of adiponectin and resistin were measured from 70 DSM-IV MDD subjects and 70 healthy controls. Depression severity was assessed with the 29-item Hamilton Depression Rating Scale.Results:The MDD group had lowered serum adiponectin levels. Regression modelling with adjustments for age, gender, overweight, several socioeconomic and lifestyle factors, coronary heart disease and metabolic syndrome showed that each 5.0 mu g/ml decrease in serum adiponectin increased the likelihood of MDD by approximately 20% (P = 0.01). The resistin levels correlated with atypical (P = 0.02), but not with typical depressive symptoms (P = 0.12).Conclusion:Our findings suggest that the lowered adiponectin levels in MDD are depression-specific and not explained by conventional low adiponectin-related factors such as such as coronary heart disease and metabolic disorders.