Association of Serum Biomarkers and Cardiac Inflammation in Patients With Atrial Fibrillation: Identification by Positron Emission Tomography.
Association of Serum Biomarkers and Cardiac Inflammation in Patients With Atrial Fibrillation: Identification by Positron Emission Tomography.
复制标题
心房颤动患者血清生物标志物与心脏炎症的关联：通过正电子发射断层扫描进行识别
DOI：
10.3389/fcvm.2021.735082
复制
发表时间：
2021
影响因子：
3.6
通讯作者：
Yang MF
中科院分区：
文献类型：
--
作者：
Chen BX;Xie B;Zhou Y;Shi L;Wang Y;Zeng L;Liu X;Yang MF
背景：外周血生物标志物可能受多种因素影响，其反映房颤患者局部心脏炎症状态的可靠性有待进一步探讨。本研究旨在通过18F-脱氧葡萄糖(FDG)心肌显像检测心外膜脂肪组织(EAT)活性，探讨房颤患者循环生物标志物与心脏局部炎症的关系。方法：收集2017~2018年接受射频消融治疗的房颤患者83例，其中持续性房颤43例，阵发性房颤40例。分别于术前、术后采血检测IL-6、IL-8、IL-10、IL-18、肿瘤坏死因子-α、热休克蛋白27、热休克蛋白60、热休克蛋白70、血小板衍生生长因子-BB、基质金属蛋白酶-2、基质金属蛋白酶-9、髓过氧化物酶、转化生长因子-β1、半乳糖胺-3和生长抑素2。在RFCA术前获取FDG图像以评估EAT活性。67例接受RFCA的患者(35例PAF和32例PSAF)定期随访27(24，29)个月。结果：PSAF患者血清hsCRP、IL-6水平高于PAF患者，而转化生长因子-β-1水平低于PAF患者。多因素Logistic回归分析显示，Gal-3(OR：1.221，95%CI：1.024~1.456，P=0.026)和MPO(OR：1.002，95%CI：1.001~1.003，P=0.027)与EAT活性独立相关。术后HSP60下降百分率与EAT下降百分率呈线性相关(r=0.455，P=0.019)。17名患者(10名PSAF和7名PAF)有房颤复发，但所选生物标志物均不能预测射频消融术后复发。结论：在房颤患者中，Gal-3与局部心脏炎症有关，而Hsp60与RFCA术后心脏炎症减轻有关。
Background: Peripheral biomarkers may be affected by various factors, their reliability in reflecting local cardiac inflammatory status in patients with atrial fibrillation (AF) needs further exploration. This prospective study was aimed to investigate the relationship between circulating biomarkers and local cardiac inflammation measured by epicardial adipose tissue (EAT) activity via 18F-fluorodeoxyglucose (FDG) imaging in AF patients. Methods: From 2017 to 2018, 83 AF patients [43 persistent AF (PsAF) and 40 paroxysmal AF (PAF)] referred for radiofrequency catheter ablation (RFCA) were recruited. Pre- and post-RFCA blood samples were collected to measure IL-6, IL-8, IL-10, IL-18, TNF-α, Hsp27, Hsp60, Hsp70, PDGF-BB, MMP-2, MMP-9, MPO, TGF-β1, Gal-3, and sST2. Pre-RFCA FDG images were obtained to assess EAT activity. Sixty-seven patients (35 PAF and 32 PsAF) received RFCA were regularly followed for 27 (24, 29) months. Results: Higher hsCRP and IL-6 and lower TGF-β1 were demonstrated in PsAF patients compared with PAF patients. Multivariate logistic regression analysis demonstrated that Gal-3 (OR: 1.221, 95% CI: 1.024–1.456, P = 0.026) and MPO (OR: 1.002, 95% CI: 1.001–1.003, P = 0.027) were independently correlated with EAT activity. The percentage decrease of Hsp60 linearly correlated with that of EAT activity post-RFCA (Spearman rs = 0.455, P = 0.019). Seventeen patients (10 PsAF and 7 PAF) had AF recurrence, but none of the selected biomarkers were predictive of post-RFCA recurrence. Conclusion: Our findings demonstrated that in patients with AF, Gal-3 correlated with local cardiac inflammation, and Hsp60 was associated with the alleviation of cardiac inflammation after RFCA.