Endocrine control of vascular permeability and induced leukocytic emigration in the rabbit uterus.
Endocrine control of vascular permeability and induced leukocytic emigration in the rabbit uterus.
复制标题
兔子子宫中血管通透性的内分泌控制和诱导白细胞迁移。
DOI：
10.1097/00007890-198211000-00004
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发表时间：
1963
影响因子：
1
通讯作者：
T. H. Brinsfield
中科院分区：
文献类型：
--
作者：
H. Hawk;G. D. Turner;T. H. Brinsfield
以前的研究表明，雌性Fischer大鼠，由同种异体DA男性，只产生低水平的凝集抗体的挑战性皮肤移植轴承父系同种异体抗原，虽然移植排斥反应是不受影响的。在这份报告中，妊娠诱导的低反应性的现象，进一步调查的因素，负责其诱导和维持。DA雄性的产次增加导致Fischer雌性的凝集抗体产生在产后对携带父系抗原的挑战皮肤移植物的抑制增加。此外，多胎妊娠也会导致移植物排斥反应受损，窝仔数越多，存活时间越长。体液或细胞低反应性，或两者兼而有之，持续数周甚至数月，在许多女性。在妊娠前切除髂淋巴结导致不太严重的抑制，在观察期（移植后21天）内没有维持，而在交配前或妊娠第7天进行脾切除术没有影响。输卵管结扎的女性暴露于多次DA射精，而没有怀孕，表现出减弱的体液免疫类似的经产女性，而那些暴露于（Fischer × DA）F1杂交滋养细胞多次在异位网站不仅有些抑制抗体反应，但也显着受损的能力，拒绝挑战同种移植物。各种抗原刺激的潜在作用和复杂性的宫内抗原处理在妊娠期间进行了讨论，这自然引起的同种异体抑制现象。
It was previously demonstrated that female Fischer rats, primiparous by allogeneic DA males, produced only low levels of agglutinating antibody to a challenge skin graft bearing paternal alloantigens, although graft rejection was unimpaired. In this report, the phenomenon of pregnancy-induced hypo responsiveness was further investigated with regard to factors responsible for its induction and maintenance. Increasing parity by DA males resulted in increased suppression of the Fischer females' agglutinating antibody production postpartum to a challenge skin graft bearing paternal antigens. Moreover, multiparity also resulted in impaired graft rejection, with greater numbers of litters causing more prolonged survival. Either humoral or cellular hypo responsiveness, or both, persisted for several weeks or even months in many females. Removal of the iliac lymph nodes prior to pregnancy resulted in less severe suppression which was not maintained through the observation period (21 days post grafting), whereas splenec-tomy either before mating or on day 7 of pregnancy had no effect. Tubal-ligated females exposed to multiple DA ejaculates, without pregnancy, manifested weakened humoral immunity similar to that of primiparous females, whereas those exposed to (Fischer X DA) F 1 hybrid tro-phoblast multiple times in ectopic sites had not only somewhat suppressed antibody responses but also significantly impaired capacity to reject the challenge al-lograft. The potential roles of various antigenic stimuli and the complexities of intrauterine antigen processing during gestation are discussed in relation to this naturally induced allosuppression phenomenon.