Noninvasive In-vivo Measurements of Microvessels by Reflection-type Micro Multipoint Laser Doppler Velocimeter
Noninvasive In-vivo Measurements of Microvessels by Reflection-type Micro Multipoint Laser Doppler Velocimeter
复制标题
反射式微型多点激光多普勒测速仪对微血管的无创体内测量
DOI：
10.1143/jjap.51.032701
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发表时间：
2012
影响因子：
1.5
通讯作者：
and Y. Kuraishi
中科院分区：
文献类型：
--
作者：
H. Ishida;T. Andoh;S. Akiguchi;T. Hachiga;M. Ishizuka;T. Shimizu;H. Shirakawa;and Y. Kuraishi
我们开发了一种微型多点激光多普勒测速仪（µ-MLDV），可以选择性地收集多普勒干涉光子。在前一份报告中[H. Ishida等人：Rev. Sci.仪器。82（2011）076104]，开发了反射型μ-MLDV，并显示了在透明人工流道上进行的演示结果。在这项研究中，我们试图使用动物进行体内实验。它可以测量绝对速度并生成血管路线的断层图像。本系统可以进行无创体内测量，检测限约为0.5 mm/s，x-y平面的空间分辨率为125 µm。因此，它能够对小静脉成像。它被用于对小鼠耳朵中的小静脉和小鼠腹部中皮肤下约1.0mm深度处的皮下血管进行成像。
We have developed a micro multipoint laser Doppler velocimeter (µ-MLDV) that enables selective collection of Doppler interference photons. In previous report [H. Ishida et al.: Rev. Sci. Instrum. 82 (2011) 076104], developed the reflection-type µ-MLDV, and showed the results of demonstrations performed on transparent artificial flow channels. In this study, we attempted to perform in-vivo experiments using animals. It can measure absolute velocity and generate tomographs of blood vessels courses. The present system can perform noninvasive in-vivo measurements with a detection limit of about 0.5 mm/s and a spatial resolution in the x–y plane of 125 µm. It is thus able to image venulae. It was used to image venulae in a mouse ear and a subcutaneous blood vessel in a mouse abdomen at a depth of about 1.0 mm below the skin.