The Symbiotic Relationship Between Scientific Quality and Animal Research Ethics.
The Symbiotic Relationship Between Scientific Quality and Animal Research Ethics.
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DOI：
10.1093/ilar/ilab023
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发表时间：
2021-08
期刊：
影响因子：
2.5
通讯作者：
Samuel A. Brill;Selena M. Guerrero-Martin;Kelly A. Metcalf Pate
中科院分区：
文献类型：
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作者：
Samuel A. Brill;Selena M. Guerrero-Martin;Kelly A. Metcalf Pate
几十年来，研究人员一直以动物为模型，以扩展我们对基本生物过程的知识，并系统地研究疾病的生理学。一般来说，公众期望与动物一起工作是有目的的，最终会获得利益。这种结果的可能性直接取决于对这些动物进行的科学研究的质量。然而，并非所有考虑动物研究伦理的框架都公开考虑科学质量。在下面的综述中，我们探讨了科学质量和动物研究伦理之间的复杂关系。我们提倡制定详细的“危害-产量分析”，用于评估生物医学动物研究，强调科学质量沿着社会效益，以证明研究的伦理合理性。我们反思失去的机会，以建立在动物研究的最佳实践，在科学家的职业生涯早期，通过引入课程，并鼓励使用的迭代考虑动物研究的伦理与实验设计的其他方面的范例。
Researchers have worked with animals as models for decades to expand our knowledge of basic biological processes and to systematically study the physiology of disease. In general, the public has an expectation that work with animals has a purpose and will ultimately reap benefits. The likelihood of such an outcome is directly dependent on the quality of the science being conducted with those animals. However, not all frameworks for consideration of the ethics around animal research overtly consider scientific quality. In the following review, we explore the complex relationship between scientific quality and animal research ethics. We advocate for the development of a detailed "Harm-Yield Analysis" for the evaluation of biomedical animal research that emphasizes scientific quality along with societal benefit in the ethical justification of the research. We reflect on the lost opportunity to establish best practices in animal research early in the career of scientists by introducing in the curriculum and encouraging the use of a paradigm of the iterative consideration of the ethics of animal research alongside other aspects of experimental design.