Stem cell labeling for noninvasive delivery and tracking in cardiovascular regenerative therapy.
Stem cell labeling for noninvasive delivery and tracking in cardiovascular regenerative therapy.
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DOI：
10.1586/erc.10.106
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发表时间：
2010-08
影响因子：
2
通讯作者：
Kraitchman DL
中科院分区：
文献类型：
--
作者：
Fu Y;Kraitchman DL
干细胞疗法的临床和基础科学研究已经显示出治疗心血管疾病的良好效果。尽管从动物研究到临床试验的快速过渡，干细胞改善心脏功能的机制尚未完全阐明。为了优化患者的细胞治疗，需要一种非侵入性的方法来评估同一受试者随时间的细胞存活、生物分布和命运。细胞标记提供了在体内成像不同细胞系的能力，并使用标准的非侵入性成像技术研究这些疗法的疗效。在本文中，我们将讨论最有前途的细胞标记技术翻译到临床心血管应用。
Clinical and basic scientific studies of stem cell-based therapies have shown promising results for cardiovascular diseases. Despite a rapid transition from animal studies to clinical trials, the mechanisms by which stem cells improve heart function are yet to be fully elucidated. To optimize cell therapies in patients will require a noninvasive means to evaluate cell survival, biodistribution and fate in the same subject over time. Cell labeling offers the ability to image distinct cell lineages in vivo and investigate the efficacy of these therapies using standard noninvasive imaging techniques. In this article, we will discuss the most promising cell labeling techniques for translation to clinical cardiovascular applications.