YKL-40 expression could be a poor prognostic marker in the breast cancer tissue
YKL-40 expression could be a poor prognostic marker in the breast cancer tissue
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DOI：
10.1007/s13277-013-1036-0
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发表时间：
2014-01-01
期刊：
影响因子：
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通讯作者：
Seo, Jae Hong
中科院分区：
文献类型：
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作者：
Kang, Eun Joo;Jung, Hoiseon;Seo, Jae Hong
YKL-40是一种参与细胞生长、迁移和炎症过程的糖蛋白。在包括乳腺癌在内的多种癌症中，血清中YKL-40水平的升高与预后不良有关。鉴于乳腺癌组织中YKL-40表达的临床意义尚不清楚，我们旨在利用免疫组织化学方法确定乳腺癌组织中YKL-40表达的预后价值。我们对手术中收集的425例乳腺癌组织进行了组织微阵列（TMA）分析。免疫组织化学染色检测YKL-40和几种乳腺癌生物标志物的表达，如醛脱氢酶1、tgf - β和gli1，以及激素受体和Her-2/neu状态。统计分析390例TMA标本中YKL-40表达与临床病理特征的关系。YKL-40在84.9%的乳腺癌组织中有不同程度的表达。YKL-40表达与雌激素受体、孕激素受体阴性相关，与tgf - β、gli1表达正相关。强YKL-40表达与Her-2/ new富集和基底样肿瘤的比例较大相关。本研究结果表明，YKL-40在乳腺癌组织中的表达与激素受体阴性和Her-2/ new富集的乳腺癌分子亚型相关，因此可被认为是一个不良的预后预测因子。
YKL-40 is a glycoprotein involved in cellular growth, migration, and the inflammatory process. Elevation in serum levels of YKL-40 has been associated with worse prognosis in various cancers, including breast cancer. Given that the clinical significance of YKL-40 expression in breast cancer tissue is unclear, we aimed to determine the prognostic value of YKL-40 expression in breast cancer tissue using immunohistochemistry. We performed tissue microarray (TMA) analysis of 425 breast cancer tissues collected during operation. Immunohistochemical staining was performed to measure expression of YKL-40 and several breast cancer biomarkers, such as aldehyde dehyadrogenase1, TGF-beta, and Gli-1 as well as hormonal receptor and Her-2/neu status. Statistical analysis of the relationship of YKL-40 expression with clinicopathological characteristics was performed for 390 TMA samples. YKL-40 was expressed to varying degrees in 84.9 % of breast cancer tissues. YKL-40 expression was correlated with estrogen receptor and progesterone receptor negativity and was positively correlated with TGF-beta and Gli-1 expression. Strong YKL-40 expression was associated with a larger proportion of Her-2/neu-enriched and basal-like tumors. The results of this study demonstrate that YKL-40 expression in breast cancer tissues is associated with hormone receptor negativity and Her-2/neu-enriched molecular subtypes of breast cancer, and therefore could be considered a poor prognostic predictor.