Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo.
Norepinephrine and beta 2-adrenergic receptor stimulation regulate CD4+ T and B lymphocyte function in vitro and in vivo.
复制标题
DOI：
--
复制
发表时间：
2001-12
影响因子：
21.1
通讯作者：
A. Kohm;V. Sanders
中科院分区：
文献类型：
--
作者：
A. Kohm;V. Sanders
历史上，去甲肾上腺素和交感神经系统与“战斗或逃跑”反应有关，它们也有助于调节体内的自主活动，如心血管功能。此外，过去30年的证据表明，去甲肾上腺素也可能调节免疫细胞的功能，保护身体免受病原体的侵害。交感神经纤维的存在和淋巴器官内去甲肾上腺素的释放代表了来自中枢神经系统的信号可能影响免疫细胞功能的机制。T细胞依赖性抗体应答对于宿主成功防御许多环境病原体至关重要。正是在这种应答过程中，CD 4 + T和B淋巴细胞被激活，分别产生细胞因子和抗体，从而产生免疫能力和保护作用。本综述的目的是讨论支持淋巴器官内释放去甲肾上腺素和CD 4 + T和B淋巴细胞表达β 2肾上腺素能受体的证据。我们还讨论了β 2-肾上腺素能受体刺激影响这些细胞在体外和体内产生的细胞因子和抗体水平的机制。在相互矛盾的结果已经报告的情况下，我们讨论了可能导致这些相互矛盾的结果的潜在变量。最后，我们讨论了在交感神经系统调节T和B淋巴细胞功能方面进行的基础研究对疾病和健康的具体影响。
Historically, norepinephrine and the sympathetic nervous system have been associated with the "fight or flight" response, and they also contribute to the regulation of autonomic activity within the body, such as cardiovascular function. In addition, evidence over the past 30 years suggests that norepinephrine may also regulate the function of immune cells that protect the body against pathogens. The presence of sympathetic nerve fibers and the release of norepinephrine within lymphoid organs represent a mechanism by which signals from the central nervous system may influence immune cell function. The T cell-dependent antibody response is essential to successful host defense against numerous environmental pathogens. It is during this response that CD4+ T and B lymphocytes are activated to produce cytokines and antibody, respectively, leading to immune competence and protection. The goal of this review is to discuss the evidence supporting the release of norepinephrine within lymphoid organs and the expression of the beta2-adrenergic receptor by CD4+ T and B lymphocytes. We also discuss the mechanisms by which beta2-adrenergic receptor stimulation affects the level of cytokine and antibody produced by these cells both in vitro and in vivo. In cases where conflicting findings have been reported, we discuss potential variables that may have contributed to these conflicting findings. To conclude, we discuss the disease- and health-specific implications of the basic research being done in the area of sympathetic nervous system regulation of T and B lymphocyte function.