Sex and age dependencies of cerebral blood volume changes during cognitive activation: a multichannel near-infrared spectroscopy study
Sex and age dependencies of cerebral blood volume changes during cognitive activation: a multichannel near-infrared spectroscopy study
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DOI：
10.1016/j.neuroimage.2004.03.050
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发表时间：
2004-08-01
期刊：
影响因子：
5.7
通讯作者：
Mikuni, M
中科院分区：
文献类型：
--
作者：
Kameyama, M;Fukuda, M;Mikuni, M
在这项研究中，我们使用多通道近红外光谱（NIRS）测量了认知任务过程中脑血红蛋白浓度的变化，并研究了局部脑血容量与性别，年龄和任务绩效之间的关系。39名健康志愿者（24名男性和15名女性;平均年龄，33.0岁）在给予知情同意后参与并执行单词流畅性任务。相对氧合血红蛋白浓度（[oxy-Hb]）的测量使用额和颞探头与两套24通道近红外光谱仪。使用协方差分析分析性别、年龄和任务表现对[oxy-Hb]变化的影响：以性别、年龄和任务表现为自变量，[oxy-Hb]变化为因变量，受教育年限为协变量。对[oxy-Hb]增加的影响是显着的，在许多渠道的额叶和颞探头的性别，这是最突出的效果，并在一些额叶渠道的年龄：[oxy-Hb]增加男性大于女性，在年轻人比中年人。对[oxy-Hb]增加的影响不显着的任务性能，但[oxy-Hb]增加的主题与低性能往往是大于那些主题与高性能。结果表明，多通道近红外光谱可以检测在认知任务的大脑激活，并澄清性别和年龄依赖性的差异，这种大脑激活。在解释脑血容量、脑血流量和脑葡萄糖代谢数据时，应考虑性别和年龄依赖性脑激活差异，如本研究所示。(C)2004爱思唯尔公司All rights reserved.
In this study, we measured the change in cerebral hemoglobin concentrations during a cognitive task using multichannel near-infrared spectroscopy (NIRS), and investigated the relationship between regional cerebral blood volume and sex, age, and task performance. Thirty-nine healthy volunteers (24 males and 15 females; mean age, 33.0 years) participated after giving their informed consent and performed a word fluency task. The relative oxy-hemoglobin concentration ([oxy-Hb]) was measured using frontal and temporal probes with two sets of 24-channel NIRS machines. The effects of sex, age, and task performance on [oxy-Hb] changes were analyzed using analysis of covariance: with sex, age, and task performance as independent variables, and [oxy-Hb] changes as dependent variables, and years of education as covariates. The effects on [oxy-Hb] increase were significant in many channels in the frontal and temporal probes for sex, that is the most prominent effect, and in a few frontal channels for age: [oxy-Hb] increases were larger in males than in females, and in the young than in the middle-aged. The effects on [oxy-Hb] increase were not significant for task performance, but [oxy-Hb] increases in subjects with low performance tended to be larger than those in subjects with high performance. The results demonstrated that multichannel NIRS could detect cerebral activation during cognitive tasks and clarify sex- and age-dependent differences in such cerebral activation. Sex- and age-dependent differences in cerebral activation, as demonstrated in the present study, should be considered when interpreting cerebral blood volume, cerebral blood flow, and cerebral glucose metabolism data. (C) 2004 Elsevier Inc. All rights reserved.