Plasma visfatin concentration as a surrogate marker for visceral fat accumulation in obese children
Plasma visfatin concentration as a surrogate marker for visceral fat accumulation in obese children
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DOI：
10.1038/oby.2007.54
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发表时间：
2008-02-01
期刊：
影响因子：
6.9
通讯作者：
Shirahata, Akira
中科院分区：
文献类型：
--
作者：
Araki, Shunsuke;Dobashi, Kazushige;Shirahata, Akira
目的：探讨血浆内脂素水平是否反映肥胖儿童内脏或皮下脂肪堆积和代谢紊乱。方法和步骤：日本肥胖儿童56例，男37例，女19例。受试者的年龄从5岁到15岁不等(10.2+/-0.3；平均+/-S.E.M.)好几年了。年龄匹配的测量内脂素的对照组由20名非肥胖儿童组成。CT测量内脏脂肪组织(VAT)和皮下脂肪组织(SAT)面积。结果：肥胖组血浆内脂素水平(14.7+/-0.9 ng/ml)高于对照组(8.6+/-0.6 ng/ml)。在单变量分析中，内脂素与年龄、身高、体重、腰围、VAT和SAT面积、甘油三酯(TG)、胰岛素和胰岛素抵抗稳态模型评估(HOMA-R)显著相关。在调整了年龄和性别后，只有VAT面积与Visfatin保持显著的偏相关，而体重、BMI-S.D.和SAT面积与Leptin则相反。血浆内脂素浓度与瘦素水平无相关性。血浆内脂素水平在正常对照组、非代谢综合征(MS)组(n=49)和MS组(n=7)之间有显著差异。血浆内脂素水平可作为预测肥胖儿童VAT面积的良好替代指标。
Objective: This study was designed to elucidate whether the plasma visfatin level reflects visceral or subcutaneous fat accumulation and metabolic derangement in obese children.Methods and Procedures: Fifty-six obese Japanese children, including 37 boys and 19 girls were enrolled in the study. The age of the subjects ranged from 5 to 15 (10.2 +/- 0.3; mean +/- s.e.m.) years. The age-matched control group for measuring visfatin consisted of 20 non-obese children. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) areas were measured by computed tomography. The plasma concentrations for visfatin and leptin were assayed by enzyme-linked immunosorbent assay kits.Results: The plasma visfatin level was higher in the obese (14.7 +/- 0.9 ng/ml) than in the control children (8.6 +/- 0.6 ng/ml). In a univariate analysis, the visfatin correlated significantly with age, height, body weight, waist circumference, VAT and SAT area, triglyceride (TG), insulin, and the homeostasis model assessment for insulin resistance (HOMA-R). After being adjusted for age and sex, only the VAT area retained significant partial correlation with visfatin, and in contrast the body weight, BMI-s.d., and SAT area with leptin. The plasma visfatin concentration was not correlated with leptin. The plasma visfatin levels in the control, non-metabolic syndrome (MS) (n = 49), and MS groups (n = 7) were significantly different from each other.Discussion: These results suggest that plasma visfatin level is a specific marker for visceral fat accumulation in obese children. As a good surrogate marker, plasma visfatin level can predict the VAT area in obese children.