Low expression of CD80 predicts for poor prognosis in patients with gastric adenocarcinoma
Low expression of CD80 predicts for poor prognosis in patients with gastric adenocarcinoma
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DOI：
10.2217/fon-2018-0420
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发表时间：
2019-02-01
期刊：
影响因子：
3.3
通讯作者：
Zhang, Xiao-shi
中科院分区：
文献类型：
--
作者：
Feng, Xing-yu;Lu, Lin;Zhang, Xiao-shi
目的：探讨CD80在胃腺癌组织中的表达及其与预后的关系。材料和方法：采用实时荧光定量PCR、免疫印迹和免疫组化方法检测胃癌组织及癌旁正常组织中CD80的表达。免疫组化双重染色初步检测CD80（+）细胞与CD8（+）细胞毒性T淋巴细胞的关系。结果：CD80在胃癌组织中的表达明显低于正常组织（P =0.002）。免疫组化结果显示，123例胃癌中49例（39.8%）CD80表达降低，且与肿瘤分化程度有关。结论：我们的数据表明，在胃腺癌患者中，CD80表达降低独立预测预后不良。
Aim: To study the expression and prognostic significance of CD80 in patients with gastric adenocarcinoma. Materials& methods: Real-time quantitative PCR, western blot and immunohistochemistry were performed to detect the expression of CD80 in gastric cancer tissues and matched adjacent normal tissues. Double immunohistochemical staining was performed to preliminary examine the relationship between CD80(+) cells and CD8(+) cytotoxic T lymphocytes. Results: The expression of CD80 was downregulated in tumor tissues compared with normal tissues (p =0.002). Immunohistochemistry analysis showed that 49 (39.8%) of 123 patients with gastric cancer demonstrated reduced CD80 expression, which was correlated with the tumor differentiation grade. Conclusion: Our data suggest that reduced CD80 expression independently predicts a poor prognosis in patients with gastric adenocarcinoma.