Estrogen supplementation modulates effects of the endocrine disrupting pollutant PCB126 in rat bone and uterus diverging effects in ovariectomized and intact animals
Estrogen supplementation modulates effects of the endocrine disrupting pollutant PCB126 in rat bone and uterus diverging effects in ovariectomized and intact animals
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DOI：
10.1016/j.tox.2004.02.022
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发表时间：
2004-07-01
期刊：
影响因子：
4.5
通讯作者：
Sahlin, L
中科院分区：
文献类型：
--
作者：
Lind, PM;Eriksen, EF;Sahlin, L
本研究的目的是比较雌激素消耗(OVX)和补充雌二醇(E2)对暴露于内分泌干扰性有机氯3，3‘，4，4’，5-五氯联苯(PCB126)的组织效应。为此，研究了两种高度依赖雌激素的组织--骨和子宫。将40只暴露于PCB126(Ip)3个月的大鼠按2×2析因设计随机分为去势/假手术组和雌二醇组(ip，23 mg/kg，每周3天)。假手术组为假手术组，假手术组为假手术+去卵巢组，卵巢切除组为去卵巢组，去卵巢+去卵巢+去卵巢组为去卵巢+去卵巢+去卵巢组，每组10只。去卵巢组、假手术组和去卵巢+雌二醇组各10只。去卵巢大鼠经PCB126+雌二醇组骨小梁体积增加(P
The aims of the present study are to compare effects of estrogen depletion (OVX) and estradiol (E2) supplementation on the tissue effects of exposure to the endocrine disrupting organochlorine 3,3',4,4',5-pentachlorobiphenyl (PCB 126). For this purpose two highly estrogen-dependent tissues, bone and uterus, were studied. Forty rats exposed to PCB 126 (ip) for 3 months (total dose 384 mug/kg body weight (bw)) were randomized in to OVX/sham operation or E2 supplementation (ip, 23 mug/kg, 3 days weekly) per vehicle (corn oil) groups in a 2 x 2 factorial design. Sham operated rats were treated with vehicle, PCB or PCB plus E2 (sham, sham + PCB and sham + PCB + E2, n = 10 per group) whereas ovariectomized were treated with vehicle, PCB or PCB plus E2(OVX, OVX + PCB and OVX + PCB + E2, n = 10 per group). As control groups served OVX or sham, and OVX + E2 (n = 10 in each group).In OVX rats PCB 126 + E2 treatment increased trabecular bone volume (TBV) (P