Correlation between body mass index and striatal dopamine transporter availability in healthy volunteers - A SPECT study
Correlation between body mass index and striatal dopamine transporter availability in healthy volunteers - A SPECT study
复制标题
DOI：
10.1016/j.neuroimage.2007.11.007
复制
发表时间：
2008-03-01
期刊：
影响因子：
5.7
通讯作者：
Lu, Ru Band
中科院分区：
文献类型：
--
作者：
Chen, Po See;Yang, Yen Kuang;Lu, Ru Band
最近的研究表明，除了下丘脑部位，纹状体多巴胺能系统可能是调节体内平衡的靶点，其可以由体重指数（BMI）表示。尽管已经报道了非常肥胖个体的纹状体多巴胺受体（DRD 2）可用性与其BMI成比例地降低，但健康个体中纹状体多巴胺系统与BMI之间的相关性仍不清楚。为了研究这种关系，50名健康志愿者的纹状体多巴胺转运蛋白（DAT）的可用性进行了测量，使用单位置发射计算机地形图（SPECT）和[99 mTc]-TRODAT-1。检测血糖、C肽、胰岛素、糖化血红蛋白和瘦素水平。我们的研究结果表明，年龄和BMI显着负相关的纹状体DAT的可用性。此外，BMI是纹状体DAT可用性的唯一重要预测因素。这些结果表明，纹状体多巴胺系统可能参与调节体重指数。因此，测量纹状体DAT可用性的分子成像研究应该考虑BMI，而不是年龄，作为协变量。(c)2007爱思唯尔公司All rights reserved.
Recent lines of research suggest that, in addition to hypothalamic sites, the striatum dopaminergic system may be a target for regulating homeostasis that may be represented by the body mass index (BMI). Although it has been reported that the striatal dopamine receptor (DRD2) availability of very obese individuals was reduced in proportion to their BMI, the correlation between the striatal dopamine system and the BMI in healthy individuals remains unclear. To investigate this relationship, the striatal dopamine transporter (DAT) availability of 50 healthy volunteers was measured using single position emission computational topography (SPECT) and [99mTc]-TRODAT-1. The serum levels of sugar, C-peptide, insulin, glycosylated hemoglobin and leptin were measured. Our results showed that age and the BMI are significantly negatively associated with the striatal DAT availability. Moreover, BMI was the only significant predictor for striatal DAT availability. These results suggest that the striatal dopamine system may be involved in body mass index regulation. Thus, molecular imaging studies measuring the striatal DAT availability should consider the BMI, rather than age, as a covariant. (c) 2007 Elsevier Inc. All rights reserved.