TRIOXACARCINS, NOVEL ANTI-TUMOR ANTIBIOTICS .1. PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITIES
TRIOXACARCINS, NOVEL ANTI-TUMOR ANTIBIOTICS .1. PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITIES
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DOI：
10.7164/antibiotics.34.1519
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
FUJIMOTO, K
中科院分区：
文献类型：
--
作者：
TOMITA, F;TAMAOKI, T;FUJIMOTO, K
在放线菌DO-45的培养液中发现了一组具有新骨架的抗肿瘤抗生素--三恶卡菌素。生产生物体随后被确定为一种新的菌株，并命名为Streptomyces bottropensis sp. nov。抗生素对革兰氏阳性菌和实验小鼠肿瘤如肉瘤180和白血病P388有活性。
A group of antitumor antibiotics with a novel skeleton, trioxacarcins, was discovered in culture broths of actinomycete strain DO-45. The producing organism was subsequently determined to be a new strain and named Streptomyces bottropensis sp. nov. The antibiotics are active against gram-positive bacteria and experimental murine tumors such as sarcoma 180 and leukemia P388.