PROTECTION BY VACCINATION AGAINST PSEUDOMONAS INFECTION AFTER THERMAL INJURY
PROTECTION BY VACCINATION AGAINST PSEUDOMONAS INFECTION AFTER THERMAL INJURY
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DOI：
10.1128/jb.96.4.867-874.1968
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发表时间：
1968-01-01
影响因子：
3.2
通讯作者：
SMALLMAN, E
中科院分区：
文献类型：
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作者：
MARKLEY, K;SMALLMAN, E
主动免疫可有效预防烧伤小鼠的假单胞菌败血症。疫苗是用 Verder 10 种不同 O 血清学类型的铜绿假单胞菌菌株以及大肠杆菌和奇异变形杆菌的细菌细胞和生长培养基制备的。尾部烧伤的小鼠可以通过特异性假单胞菌疫苗和在较小程度上通过由细菌细胞或它们生长的培养基制备的非特异性假单胞菌疫苗来显着保护其免受局部假单胞菌攻击。该疫苗在热创伤之前或之后施用是有效的。在更广泛的臀部烧伤后，只有当攻击推迟到烧伤后 4 天时，热损伤后注射的特定疫苗的保护作用才显着；保护水平低于烧伤较小的小鼠。
Active immunization is effective in the prophylaxis ofPseudomonassepticemia in burned mice. Vaccines were prepared from bacterial cells and growth medium of Verder's 10 different O serological types ofPseudomonas aeruginosastrains, as well as fromEscherichia coliandProteus mirabilis. Mice given a tail burn could be significantly protected against a localPseudomonaschallenge by both specific and, to a lesser extent, by nonspecificPseudomonasvaccines prepared either from bacterial cells or from the medium in which they were grown. The vaccine was effective when administered prior to or after thermal trauma. After a more extensive rump burn, the protective effect of a specific vaccine given after thermal injury was significant only when the challenge was postponed until 4 days postburn; the level of protection was less than in the mice with smaller burns.